Phosphorylation of the histone H2AX is an early response to DNA damage and a marker of aging. γH2AX appears in foci within interkinetic/apoptotic nuclei and mitotic chromosomes from development to senescence. Immunoreactivity is mainly detected in neurogenetic areas, but also in the adult and senescent cerebral cortex. γH2AX in neurogenetic areas is temporally and functionally related to proliferation and apoptosis of neuronal precursors (type C transit amplifying cells in SVZ and granule cell precursors in cerebellum). In senescent SVZ cells, displaying an extremely long cell cycle and slow proliferation rate, H2AX phosphorylation is primarily related to DNA repair
Expression of phosphorylated H2AX histone in the aging brain and its relationship with slowly cycling neurons
MERIGHI, Adalberto
2015-01-01
Abstract
Phosphorylation of the histone H2AX is an early response to DNA damage and a marker of aging. γH2AX appears in foci within interkinetic/apoptotic nuclei and mitotic chromosomes from development to senescence. Immunoreactivity is mainly detected in neurogenetic areas, but also in the adult and senescent cerebral cortex. γH2AX in neurogenetic areas is temporally and functionally related to proliferation and apoptosis of neuronal precursors (type C transit amplifying cells in SVZ and granule cell precursors in cerebellum). In senescent SVZ cells, displaying an extremely long cell cycle and slow proliferation rate, H2AX phosphorylation is primarily related to DNA repair
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