The therapeutic landscape of metastatic melanoma drastically changed after the introduction of targeted therapies and immunotherapy, in particular immune checkpoints inhibitors (ICI). In recent years, positive effects on the immune system associated to radiotherapy (RT) were discovered, and radiation has been tested in combination with ICI in both pre-clinical and clinical studies (many of them still ongoing). We here summarize the rationale and the preliminary clinical results of this approach.
Titolo: | Radiotherapy and immune checkpoints inhibitors for advanced melanoma | |
Autori Riconosciuti: | ||
Autori: | Filippi, Andrea Riccardo; Fava, Paolo; Badellino, Serena; Astrua, Chiara; Ricardi, Umberto; Quaglino, Pietro | |
Data di pubblicazione: | 2016 | |
Abstract: | The therapeutic landscape of metastatic melanoma drastically changed after the introduction of targeted therapies and immunotherapy, in particular immune checkpoints inhibitors (ICI). In recent years, positive effects on the immune system associated to radiotherapy (RT) were discovered, and radiation has been tested in combination with ICI in both pre-clinical and clinical studies (many of them still ongoing). We here summarize the rationale and the preliminary clinical results of this approach. | |
Volume: | 120 | |
Fascicolo: | 1 | |
Pagina iniziale: | 1 | |
Pagina finale: | 12 | |
Digital Object Identifier (DOI): | 10.1016/j.radonc.2016.06.003 | |
Parole Chiave: | Immunotherapy; Melanoma; Radiotherapy; Stereotactic radiotherapy | |
Rivista: | RADIOTHERAPY AND ONCOLOGY | |
Appare nelle tipologie: | 03B-Review in Rivista / Rassegna della Lett. in Riv. / Nota Critica |
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