The therapeutic landscape of metastatic melanoma drastically changed after the introduction of targeted therapies and immunotherapy, in particular immune checkpoints inhibitors (ICI). In recent years, positive effects on the immune system associated to radiotherapy (RT) were discovered, and radiation has been tested in combination with ICI in both pre-clinical and clinical studies (many of them still ongoing). We here summarize the rationale and the preliminary clinical results of this approach.

Radiotherapy and immune checkpoints inhibitors for advanced melanoma

FILIPPI, Andrea Riccardo;FAVA, PAOLO;BADELLINO, Serena;ASTRUA, Chiara;RICARDI, Umberto;QUAGLINO, Pietro
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2016-01-01

Abstract

The therapeutic landscape of metastatic melanoma drastically changed after the introduction of targeted therapies and immunotherapy, in particular immune checkpoints inhibitors (ICI). In recent years, positive effects on the immune system associated to radiotherapy (RT) were discovered, and radiation has been tested in combination with ICI in both pre-clinical and clinical studies (many of them still ongoing). We here summarize the rationale and the preliminary clinical results of this approach.
2016
120
1
1
12
Immunotherapy; Melanoma; Radiotherapy; Stereotactic radiotherapy
Filippi, Andrea Riccardo; Fava, Paolo; Badellino, Serena; Astrua, Chiara; Ricardi, Umberto; Quaglino, Pietro
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1575955
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