A series of poly(N-isopropylacrylamide-co-acrylamide) thermoresponsive random copolymers with different mo- lecular weights and composition were synthesized and characterized by attenuated total reflectance Fourier-transform infrared (ATR-FTIR), differential scanning calorimetry (DSC), size exclusion chromatography (SEC) and proton nuclear magnetic resonance (NMR) spectroscopy. The lower critical solution temperatures (LCST) of the copolymers were tuned by changing the mole ratios of monomers. Copolymer with highest molecular weight and LCST (41.2 °C) was grafted on SBA-15 type mesoporous silica particles by a two-step polymer grafting procedure. Bare SBA-15 and the thermoresponsive copolymer- grafted (hybrid) SBA-15 particles were fully characterized by scanning electron microscope (SEM), ATR-FTIR, thermo- gravimetric analysis (TGA) and Brunauer-Emmett-Teller (BET) analyses. The hybrid particles were tested for their efficiency as temperature-sensitive systems for dermal delivery of the antioxidant rutin (quercetin-3-O-rutinoside). Improved control over rutin release by hybrid particles was obtained which makes them attractive hybrid materials for drug delivery.

Thermoresponsive copolymer-grafted SBA-15 porous silica particles for temperature-triggered topical delivery systems

SCALARONE, Dominique Maria;BRUNELLA, VALENTINA GIOVANNA;UGAZIO, Elena;SAPINO, Simona;BERLIER, Gloria
2017

Abstract

A series of poly(N-isopropylacrylamide-co-acrylamide) thermoresponsive random copolymers with different mo- lecular weights and composition were synthesized and characterized by attenuated total reflectance Fourier-transform infrared (ATR-FTIR), differential scanning calorimetry (DSC), size exclusion chromatography (SEC) and proton nuclear magnetic resonance (NMR) spectroscopy. The lower critical solution temperatures (LCST) of the copolymers were tuned by changing the mole ratios of monomers. Copolymer with highest molecular weight and LCST (41.2 °C) was grafted on SBA-15 type mesoporous silica particles by a two-step polymer grafting procedure. Bare SBA-15 and the thermoresponsive copolymer- grafted (hybrid) SBA-15 particles were fully characterized by scanning electron microscope (SEM), ATR-FTIR, thermo- gravimetric analysis (TGA) and Brunauer-Emmett-Teller (BET) analyses. The hybrid particles were tested for their efficiency as temperature-sensitive systems for dermal delivery of the antioxidant rutin (quercetin-3-O-rutinoside). Improved control over rutin release by hybrid particles was obtained which makes them attractive hybrid materials for drug delivery.
EXPRESS POLYMER LETTERS
11
2
96
105
https://doi.org/10.3144/expresspolymlett.2017.11
Smart polymers, lower critical solution temperature, nanomaterial, SBA-15 particles, temperature-triggered delivery to skin
Sushilkumar A. Jadhav; Scalarone, Dominique; Brunella, Valentina; Ugazio, Elena; Sapino, Simona; Berlier, Gloria
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1632043
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