Intracellular calcium (Ca(2+) ) signals are key regulators of multiple cellular functions, both healthy and physiopathological. It is therefore unsurprising that several cancers present a strong Ca(2+) homeostasis deregulation. Among the various hallmarks of cancer disease, a particular role is played by metastasis, which has a critical impact on cancer patients' outcome. Importantly, Ca(2+) signalling has been reported to control multiple aspects of the adaptive metastatic cancer cell behaviour, including epithelial-mesenchymal transition, cell migration, local invasion and induction of angiogenesis (see Abstract Figure). In this context Ca(2+) signalling is considered to be a substantial intracellular tool that regulates the dynamicity and complexity of the metastatic cascade. In the present study we review the spatial and temporal organization of Ca(2+) fluxes, as well as the molecular mechanisms involved in metastasis, analysing the key steps which regulate initial tumour spread.

Molecular mechanisms of tumour invasion: regulation by calcium signals

FIORIO PLA, Alessandra;
2017

Abstract

Intracellular calcium (Ca(2+) ) signals are key regulators of multiple cellular functions, both healthy and physiopathological. It is therefore unsurprising that several cancers present a strong Ca(2+) homeostasis deregulation. Among the various hallmarks of cancer disease, a particular role is played by metastasis, which has a critical impact on cancer patients' outcome. Importantly, Ca(2+) signalling has been reported to control multiple aspects of the adaptive metastatic cancer cell behaviour, including epithelial-mesenchymal transition, cell migration, local invasion and induction of angiogenesis (see Abstract Figure). In this context Ca(2+) signalling is considered to be a substantial intracellular tool that regulates the dynamicity and complexity of the metastatic cascade. In the present study we review the spatial and temporal organization of Ca(2+) fluxes, as well as the molecular mechanisms involved in metastasis, analysing the key steps which regulate initial tumour spread.
595
10
3063
3075
calcium channel; calcium signalling; cancer cells
Iamshanova, Oksana; Fiorio Pla, Alessandra; Prevarskaya, Natalia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1633436
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