Monitoring response and resistance to kinase inhibitors is essential to precision cancer medicine, and is usually investigated by molecular profiling of a tissue biopsy obtained at progression. However, tumor heterogeneity and tissue sampling bias limit the effectiveness of this strategy. In addition, tissue biopsies are not always feasible and are associated with risks due to the invasiveness of the procedure. To overcome these limitations, blood-based liquid biopsy analysis has proven effective to non-invasively follow tumor's clonal evolution.

Tracking a CAD-ALK gene rearrangement in urine and blood of a colorectal cancer patient treated with an ALK inhibitor

SIRAVEGNA, GIULIA;NOVARA, Luca;BUSCARINO, MICHELA;CRISAFULLI, GIOVANNI;BARTOLINI, Alice;DI NICOLANTONIO, Federica;BARDELLI, Alberto
Co-last
2017

Abstract

Monitoring response and resistance to kinase inhibitors is essential to precision cancer medicine, and is usually investigated by molecular profiling of a tissue biopsy obtained at progression. However, tumor heterogeneity and tissue sampling bias limit the effectiveness of this strategy. In addition, tissue biopsies are not always feasible and are associated with risks due to the invasiveness of the procedure. To overcome these limitations, blood-based liquid biopsy analysis has proven effective to non-invasively follow tumor's clonal evolution.
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https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mdx095
ALK inhibitor; ALK translocation; circulating DNA; colorectal cancer; liquid biopsy; trans-renal DNA
Siravegna, G; Sartore-Bianchi, A; Mussolin, B; Cassingena, A; Amatu, A; Novara, L; Buscarino, M; Corti, G; Crisafulli, G; Bartolini, A; Tosi, F; Erlander, M; Di Nicolantonio, F; Siena, S; Bardelli, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1634243
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