Heart Failure with preserved Ejection Fraction (HFpEF) is a prevalent disease with considerable individual and societal burden. HFpEF patients often suffer from multiple pathological conditions thatcomplicate management and adversely affect outcome, including pulmonary hypertension and chronic obstructive pulmonary disease (COPD). To date, no treatment proved to be fully effective in reducing morbidity and mortality in HFpEF, possibly due to an incomplete understanding of the underlying molecular mechanisms.

Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF)

SALA, VALENTINA;MARGARIA, JEAN PIERO;MURABITO, ALESSANDRA;Morello, Fulvio;GHIGO, Alessandra;HIRSCH, Emilio
Last
2017

Abstract

Heart Failure with preserved Ejection Fraction (HFpEF) is a prevalent disease with considerable individual and societal burden. HFpEF patients often suffer from multiple pathological conditions thatcomplicate management and adversely affect outcome, including pulmonary hypertension and chronic obstructive pulmonary disease (COPD). To date, no treatment proved to be fully effective in reducing morbidity and mortality in HFpEF, possibly due to an incomplete understanding of the underlying molecular mechanisms.
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Chronic obstructive pulmonary disease; PDE inhibitors; Phosphodieserases; Phosphoinositide-3 kinase inhibitors; Endothelium, Vascular; Heart Failure; Humans; Hypertension, Pulmonary; Inflammation; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive; Stroke Volume; Cardiology and Cardiovascular Medicine; Physiology (medical); Emergency Medicine; Medicine (all)
Sala, Valentina; Margaria, Jean Piero; Murabito, Alessandra; Morello, Fulvio; Ghigo, Alessandra; Hirsch, Emilio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1634546
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