MARGARIA, JEAN PIERO
MARGARIA, JEAN PIERO
BIOTECNOLOGIE MOLECOLARI E SCIENZE PER LA SALUTE
A novel multiplex qrt-pcr assay to detect sars-cov-2 infection: High sensitivity and increased testing capacity
2020-01-01 Petrillo S.; Carrà Giovanna; Bottino P.; Zanotto E.; De Santis M.C.; Margaria J.P.; Giorgio A.; Mandili G.; Martini M.; Cavallo R.; Barberio Davide; Altruda F.
Cardiac gene therapy with phosphodiesterase PDE4B in a mouse model of heart failure
2018-01-25
Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure
2020-01-01 Karam S.; Margaria J.P.; Bourcier A.; Mika D.; Varin A.; Bedioune I.; Lindner M.; Bouadjel K.; Dessillons M.; Gaudin F.; Lefebvre F.; Mateo P.; Lechene P.; Gomez S.; Domergue V.; Robert P.; Coquard C.; Algalarrondo V.; Samuel J.-L.; Michel J.-B.; Charpentier F.; Ghigo A.; Hirsch E.; Fischmeister R.; Leroy J.; Vandecasteele G.
Class II PI3K Functions in Cell Biology and Disease
2019-01-01 Gulluni, Federico; De Santis, Maria Chiara; Margaria, Jean Piero; Martini, Miriam; Hirsch, Emilio
Gene therapy with phosphodiesterases 2A and 4B ameliorates heart failure and arrhythmias by improving subcellular cAMP compartmentation
2024-01-01 Pavlaki, Nikoleta; Froese, Alexander; Li, Wener; De Jong, Kirstie A; Geertz, Birgit; Subramanian, Hariharan; Mohagaonkar, Sanika; Luo, Xiaojing; Schubert, Mario; Wiegmann, Robert; Margaria, Jean Piero; Ghigo, Alessandra; Kämmerer, Susanne; Hirsch, Emilio; El-Armouche, Ali; Guan, Kaomei; Nikolaev, Viacheslav O
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs
2017-01-01 Pirali, Tracey; Ciraolo, Elisa; Aprile, Silvio; Massarotti, Alberto; Berndt, Alex; Griglio, Alessia; Serafini, Marta; Mercalli, Valentina; Landoni, Clarissa; Campa, Carlo Cosimo; Margaria, Jean Piero; Silva, Rangel L.; Grosa, Giorgio; Sorba, Giovanni; Williams, Roger; Hirsch, Emilio; Tron, Gian Cesare
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
2018-01-01 Campa, Carlo C.; Silva, Rangel L.; Margaria, Jean P.; Pirali, Tracey; Mattos, Matheus S.; Kraemer, Lucas R.; Reis, Diego C.; Grosa, Giorgio; Copperi, Francesca; Dalmarco, Eduardo M.; Lima-Júnior, Roberto C. P.; Aprile, Silvio; Sala, Valentina; Dal Bello, Federica; Prado, Douglas Silva; Alves-Filho, Jose Carlos; Medana, Claudio; Cassali, Geovanni D.; Tron, Gian Cesare; Teixeira, Mauro M.; Ciraolo, Elisa; Russo, Remo C.; Hirsch, Emilio
Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer
2023-01-01 De Santis, Maria Chiara; Gozzelino, Luca; Margaria, Jean Piero; Costamagna, Andrea; Ratto, Edoardo; Gulluni, Federico; Di Gregorio, Enza; Mina, Erica; Lorito, Nicla; Bacci, Marina; Lattanzio, Rossano; Sala, Gianluca; Cappello, Paola; Novelli, Francesco; Giovannetti, Elisa; Vicentini, Caterina; Andreani, Silvia; Delfino, Pietro; Corbo, Vincenzo; Scarpa, Aldo; Porporato, Paolo Ettore; Morandi, Andrea; Hirsch, Emilio; Martini, Miriam
Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function
2017-01-01 Gulluni, Federico; Martini, Miriam; De Santis, Maria Chiara; Campa, Carlo Cosimo; Ghigo, Alessandra; Margaria, Jean Piero; Ciraolo, Elisa; Franco, Irene; Ala, Ugo; Annaratone, Laura; Disalvatore, Davide; Bertalot, Giovanni; Viale, Giuseppe; Noatynska, Anna; Compagno, Mara; Sigismund, Sara; Montemurro, Filippo; Thelen, Marcus; Fan, Fan; Meraldi, Patrick; Marchiò, Caterina; Pece, Salvatore; Sapino, Anna; Chiarle, Roberto; Di Fiore, Pier Paolo; Hirsch, Emilio
Phosphoinositide 3-Kinase Gamma Inhibition Protects from Anthracycline Cardiotoxicity and Reduces Tumor Growth
2018-01-01 Li, Mingchuan; Sala, Valentina; De Santis, Maria Chiara; Cimino, James; Cappello, Paola; Pianca, Nicola; Di Bona, Anna; Margaria, Jean Piero; Martini, Miriam; Lazzarini, Edoardo; Pirozzi, Flora; Rossi, Luca; Franco, Irene; Bornbaum, Julia; Heger, Jacqueline; Rohrbach, Susanne; Perino, Alessia; Tocchetti, Carlo G; Lima, Braulio H F; Teixeira, Mauro M; Porporato, Paolo E; Schulz, Rainer; Angelini, Annalisa; Sandri, Marco; Ameri, Pietro; Sciarretta, Sebastiano; Lima-Júnior, Roberto César P; Mongillo, Marco; Zaglia, Tania; Morello, Fulvio; Novelli, Francesco; Hirsch, Emilio; Ghigo, Alessandra
Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation
2016-01-01 Franco, Irene; Margaria, Jean Piero; De Santis, Maria Chiara; Ranghino, Andrea; Monteyne, Daniel; Chiaravalli, Marco; Pema, Monika; Campa, Carlo Cosimo; Ratto, Edoardo; Gulluni, Federico; Perez-Morga, David; Somlo, Stefan; Merlo, Giorgio R; Boletta, Alessandra; Hirsch, Emilio
Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer
2022-01-01 Li H.; Prever L.; Hsu M.Y.; Lo W.-T.; Margaria J.P.; De Santis M.C.; Zanini C.; Forni M.; Novelli F.; Pece S.; Di Fiore P.P.; Porporato P.E.; Martini M.; Belabed H.; Nazare M.; Haucke V.; Gulluni F.; Hirsch E.
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation
2021-01-01 Gulluni F.; Prever L.; Li H.; Krafcikova P.; Corrado I.; Lo W.-T.; Margaria J.P.; Chen A.; de Santis M.C.; Cnudde S.J.; Fogerty J.; Yuan A.; Massarotti A.; Sarijalo N.T.; Vadas O.; Williams R.L.; Thelen M.; Powell D.R.; Schueler M.; Wiesener M.S.; Balla T.; Baris H.N.; Tiosano D.; McDermott B.M.; Perkins B.D.; Ghigo A.; Martini M.; Haucke V.; Boura E.; Merlo G.R.; Buchner D.A.; Hirsch E.
PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function.
2014-01-01 Franco I;Gulluni F;Campa CC;Costa C;Margaria JP;Ciraolo E;Martini M;Monteyne D;De Luca E;Germena G;Posor Y;Maffucci T;Marengo S;Haucke V;Falasca M;Perez-Morga D;Boletta A;Merlo GR;Hirsch E
Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes
2018-01-01 Campa, Carlo Cosimo*; Margaria, Jean Piero; Derle, Abhishek; Del Giudice, Marco; De Santis, Maria Chiara; Gozzelino, Luca; Copperi, Francesca; Bosia, Carla; Hirsch, Emilio
Response by Vandecasteele et al to Letter Regarding Article, âCardiac Overexpression of PDE4B Blunts Î-Adrenergic Response and Maladaptive Remodeling in Heart Failureâ
2021-01-01 Vandecasteele G.; Mika D.; Margaria J.P.; Ghigo A.; Hirsch E.; Leroy J.; Fischmeister R.
Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5
2018-01-01 Jenkins M.L.; Margaria J.P.; Stariha J.T.B.; Hoffmann R.M.; McPhail J.A.; Hamelin D.J.; Boulanger M.J.; Hirsch E.; Burke J.E.
The PI3K/Akt/mTOR pathway in polycystic kidney disease: A complex interaction with polycystins and primary cilium
2020-01-01 Margaria J.P.; Campa C.C.; De Santis M.C.; Hirsch E.; Franco I.
Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF)
2017-01-01 Sala, Valentina; Margaria, Jean Piero; Murabito, Alessandra; Morello, Fulvio; Ghigo, Alessandra; Hirsch, Emilio
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A novel multiplex qrt-pcr assay to detect sars-cov-2 infection: High sensitivity and increased testing capacity | 2020 | Petrillo S.; Carrà Giovanna; Bottino P.; Zanotto E.; De Santis M.C.; Margaria J.P.; Giorgio A.; Mandili G.; Martini M.; Cavallo R.; Barberio Davide; Altruda F. | |
| Cardiac gene therapy with phosphodiesterase PDE4B in a mouse model of heart failure | 2018 | - | |
| Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure | 2020 | Karam S.; Margaria J.P.; Bourcier A.; Mika D.; Varin A.; Bedioune I.; Lindner M.; Bouadjel K.; Dessillons M.; Gaudin F.; Lefebvre F.; Mateo P.; Lechene P.; Gomez S.; Domergue V.; Robert P.; Coquard C.; Algalarrondo V.; Samuel J.-L.; Michel J.-B.; Charpentier F.; Ghigo A.; Hirsch E.; Fischmeister R.; Leroy J.; Vandecasteele G. | |
| Class II PI3K Functions in Cell Biology and Disease | 2019 | Gulluni, Federico; De Santis, Maria Chiara; Margaria, Jean Piero; Martini, Miriam; Hirsch, Emilio | |
| Gene therapy with phosphodiesterases 2A and 4B ameliorates heart failure and arrhythmias by improving subcellular cAMP compartmentation | 2024 | Pavlaki, Nikoleta; Froese, Alexander; Li, Wener; De Jong, Kirstie A; Geertz, Birgit; Subramanian, Hariharan; Mohagaonkar, Sanika; Luo, Xiaojing; Schubert, Mario; Wiegmann, Robert; Margaria, Jean Piero; Ghigo, Alessandra; Kämmerer, Susanne; Hirsch, Emilio; El-Armouche, Ali; Guan, Kaomei; Nikolaev, Viacheslav O | |
| Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs | 2017 | Pirali, Tracey; Ciraolo, Elisa; Aprile, Silvio; Massarotti, Alberto; Berndt, Alex; Griglio, Alessia; Serafini, Marta; Mercalli, Valentina; Landoni, Clarissa; Campa, Carlo Cosimo; Margaria, Jean Piero; Silva, Rangel L.; Grosa, Giorgio; Sorba, Giovanni; Williams, Roger; Hirsch, Emilio; Tron, Gian Cesare | |
| Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis | 2018 | Campa, Carlo C.; Silva, Rangel L.; Margaria, Jean P.; Pirali, Tracey; Mattos, Matheus S.; Kraemer, Lucas R.; Reis, Diego C.; Grosa, Giorgio; Copperi, Francesca; Dalmarco, Eduardo M.; Lima-Júnior, Roberto C. P.; Aprile, Silvio; Sala, Valentina; Dal Bello, Federica; Prado, Douglas Silva; Alves-Filho, Jose Carlos; Medana, Claudio; Cassali, Geovanni D.; Tron, Gian Cesare; Teixeira, Mauro M.; Ciraolo, Elisa; Russo, Remo C.; Hirsch, Emilio | |
| Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer | 2023 | De Santis, Maria Chiara; Gozzelino, Luca; Margaria, Jean Piero; Costamagna, Andrea; Ratto, Edoardo; Gulluni, Federico; Di Gregorio, Enza; Mina, Erica; Lorito, Nicla; Bacci, Marina; Lattanzio, Rossano; Sala, Gianluca; Cappello, Paola; Novelli, Francesco; Giovannetti, Elisa; Vicentini, Caterina; Andreani, Silvia; Delfino, Pietro; Corbo, Vincenzo; Scarpa, Aldo; Porporato, Paolo Ettore; Morandi, Andrea; Hirsch, Emilio; Martini, Miriam | |
| Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function | 2017 | Gulluni, Federico; Martini, Miriam; De Santis, Maria Chiara; Campa, Carlo Cosimo; Ghigo, Alessandra; Margaria, Jean Piero; Ciraolo, Elisa; Franco, Irene; Ala, Ugo; Annaratone, Laura; Disalvatore, Davide; Bertalot, Giovanni; Viale, Giuseppe; Noatynska, Anna; Compagno, Mara; Sigismund, Sara; Montemurro, Filippo; Thelen, Marcus; Fan, Fan; Meraldi, Patrick; Marchiò, Caterina; Pece, Salvatore; Sapino, Anna; Chiarle, Roberto; Di Fiore, Pier Paolo; Hirsch, Emilio | |
| Phosphoinositide 3-Kinase Gamma Inhibition Protects from Anthracycline Cardiotoxicity and Reduces Tumor Growth | 2018 | Li, Mingchuan; Sala, Valentina; De Santis, Maria Chiara; Cimino, James; Cappello, Paola; Pianca, Nicola; Di Bona, Anna; Margaria, Jean Piero; Martini, Miriam; Lazzarini, Edoardo; Pirozzi, Flora; Rossi, Luca; Franco, Irene; Bornbaum, Julia; Heger, Jacqueline; Rohrbach, Susanne; Perino, Alessia; Tocchetti, Carlo G; Lima, Braulio H F; Teixeira, Mauro M; Porporato, Paolo E; Schulz, Rainer; Angelini, Annalisa; Sandri, Marco; Ameri, Pietro; Sciarretta, Sebastiano; Lima-Júnior, Roberto César P; Mongillo, Marco; Zaglia, Tania; Morello, Fulvio; Novelli, Francesco; Hirsch, Emilio; Ghigo, Alessandra | |
| Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation | 2016 | Franco, Irene; Margaria, Jean Piero; De Santis, Maria Chiara; Ranghino, Andrea; Monteyne, Daniel; Chiaravalli, Marco; Pema, Monika; Campa, Carlo Cosimo; Ratto, Edoardo; Gulluni, Federico; Perez-Morga, David; Somlo, Stefan; Merlo, Giorgio R; Boletta, Alessandra; Hirsch, Emilio | |
| Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer | 2022 | Li H.; Prever L.; Hsu M.Y.; Lo W.-T.; Margaria J.P.; De Santis M.C.; Zanini C.; Forni M.; Novelli F.; Pece S.; Di Fiore P.P.; Porporato P.E.; Martini M.; Belabed H.; Nazare M.; Haucke V.; Gulluni F.; Hirsch E. | |
| PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation | 2021 | Gulluni F.; Prever L.; Li H.; Krafcikova P.; Corrado I.; Lo W.-T.; Margaria J.P.; Chen A.; de Santis M.C.; Cnudde S.J.; Fogerty J.; Yuan A.; Massarotti A.; Sarijalo N.T.; Vadas O.; Williams R.L.; Thelen M.; Powell D.R.; Schueler M.; Wiesener M.S.; Balla T.; Baris H.N.; Tiosano D.; McDermott B.M.; Perkins B.D.; Ghigo A.; Martini M.; Haucke V.; Boura E.; Merlo G.R.; Buchner D.A.; Hirsch E. | |
| PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function. | 2014 | Franco I;Gulluni F;Campa CC;Costa C;Margaria JP;Ciraolo E;Martini M;Monteyne D;De Luca E;Germena G;Posor Y;Maffucci T;Marengo S;Haucke V;Falasca M;Perez-Morga D;Boletta A;Merlo GR;Hirsch E | |
| Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes | 2018 | Campa, Carlo Cosimo*; Margaria, Jean Piero; Derle, Abhishek; Del Giudice, Marco; De Santis, Maria Chiara; Gozzelino, Luca; Copperi, Francesca; Bosia, Carla; Hirsch, Emilio | |
| Response by Vandecasteele et al to Letter Regarding Article, âCardiac Overexpression of PDE4B Blunts Î-Adrenergic Response and Maladaptive Remodeling in Heart Failureâ | 2021 | Vandecasteele G.; Mika D.; Margaria J.P.; Ghigo A.; Hirsch E.; Leroy J.; Fischmeister R. | |
| Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 | 2018 | Jenkins M.L.; Margaria J.P.; Stariha J.T.B.; Hoffmann R.M.; McPhail J.A.; Hamelin D.J.; Boulanger M.J.; Hirsch E.; Burke J.E. | |
| The PI3K/Akt/mTOR pathway in polycystic kidney disease: A complex interaction with polycystins and primary cilium | 2020 | Margaria J.P.; Campa C.C.; De Santis M.C.; Hirsch E.; Franco I. | |
| Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF) | 2017 | Sala, Valentina; Margaria, Jean Piero; Murabito, Alessandra; Morello, Fulvio; Ghigo, Alessandra; Hirsch, Emilio |