Backround: The effect of methadone (MET) during therapy with novel direct-acting antiviral agents is still not fully understood. Currently, no data are available about the influence of MET on daclatasvir (DCV) plasma levels in patients affected by chronic hepatitis C (CHC). The aim of this study was to assess the DCV plasma concentrations in patients treated with sofosbuvir (SOF) plus DCV, with or without ribavirin (RBV) and with or without MET.

Daclatasvir Plasma Levels in a Cohort of Patients with Hepatitis C Virus Infection Taking Methadone: A Prospective Analysis

Boglione, Lucio
First
;
De Nicolò, Amedeo;Mornese Pinna, Simone;Cusato, Jessica;Di Perri, Giovanni;D'Avolio, Antonio
Last
2018

Abstract

Backround: The effect of methadone (MET) during therapy with novel direct-acting antiviral agents is still not fully understood. Currently, no data are available about the influence of MET on daclatasvir (DCV) plasma levels in patients affected by chronic hepatitis C (CHC). The aim of this study was to assess the DCV plasma concentrations in patients treated with sofosbuvir (SOF) plus DCV, with or without ribavirin (RBV) and with or without MET.
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Cirrhotic; Daclatasvir; Hepatitis C virus; Methadone; Pharmacokinetic; Therapeutic drug monitoring
Boglione, Lucio; De Nicolò, Amedeo; Mornese Pinna, Simone; Cusato, Jessica; Cariti, Giuseppe; Di Perri, Giovanni; D'Avolio, Antonio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1678719
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