Vitamin D (VD) influences genetic expression through its receptor (VDR). VD pathway gene polymorphisms seem to influence antiviral drug pharmacokinetics and therapeutic outcome/toxicity. We investigated the association between daclatasvir (DCV) plasma concentrations and genetic variants (SNPs) associated with the VD pathway.
Vitamin D pathway gene polymorphisms affecting daclatasvir plasma concentration at 2 weeks and 1 month of therapy
Cusato, Jessica
Co-first
;Nicolò, Amedeo DeCo-first
;Boglione, Lucio;Favata, Fabio;Ariaudo, Alessandra;Pinna, Simone Mornese;Carcieri, Chiara;GUIDO, FEDERICA;Perri, Giovanni Di;D'Avolio, AntonioLast
2018
Abstract
Vitamin D (VD) influences genetic expression through its receptor (VDR). VD pathway gene polymorphisms seem to influence antiviral drug pharmacokinetics and therapeutic outcome/toxicity. We investigated the association between daclatasvir (DCV) plasma concentrations and genetic variants (SNPs) associated with the VD pathway.
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