The Gd(iii)-complexes of three novel HP-DO3A-like ligands have been investigated to assess the relationship between relaxometry and intramolecular catalysis of the proton exchange. The structures of these ligands differ from the parent HP-DO3A because the methyl group of the hydroxy-propyl arm has been replaced by-Ph-OH,-Ph-NH2 and-Ph-COOH, respectively. The phenol, amine and carboxylate functionalities display an intramolecular H-bonding with the coordinated hydroxyl moiety that affects either the pK values of the involved functionalities and the rate of the proton exchange process.

Exploring the intramolecular catalysis of the proton exchange process to modulate the relaxivity of Gd(iii)-complexes of HP-DO3A-like ligands

Carnovale, Irene Maria;Lolli, Marco Lucio;Serra, Sonia Colombo;Mingo, Alberto Fringuello;Napolitano, Roberta;Aime, Silvio
2018-01-01

Abstract

The Gd(iii)-complexes of three novel HP-DO3A-like ligands have been investigated to assess the relationship between relaxometry and intramolecular catalysis of the proton exchange. The structures of these ligands differ from the parent HP-DO3A because the methyl group of the hydroxy-propyl arm has been replaced by-Ph-OH,-Ph-NH2 and-Ph-COOH, respectively. The phenol, amine and carboxylate functionalities display an intramolecular H-bonding with the coordinated hydroxyl moiety that affects either the pK values of the involved functionalities and the rate of the proton exchange process.
2018
54
72
10056-10059
10059
NUCLEAR-MAGNETIC-RESONANCE; MRI CONTRAST AGENTS; BASE CATALYSIS; COMPLEXES; DYNAMICS; GADOLINIUM(III)
Carnovale, Irene Maria; Lolli, Marco Lucio; Serra, Sonia Colombo; Mingo, Alberto Fringuello; Napolitano, Roberta; Boi, Valeria; Guidolin, Nicol; Lattu...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1686474
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