The coiled-coil is a widespread protein structural motif known to have a stabilization function and to be involved in key interactions in cells and organisms. Here we introduce a new program (PS-COILS) to address the problem of coiled-coil prediction. Furthermore, we select a new structurally-annotated and freely-available dataset of coiled-coil structures. We also show that PS-COILS performs better than the other available methods on the new dataset and we propose a new scoring schema that accounts for per-residue, per-segment and per-protein accuracy. The dataset and the PS-COILS code (under GPL-license) are available at www.biocomp.unibo.it/ lisa/CC. PS-COILS is also available at www.plone4bio.org through subversion interface.

PS-Coils: A new method for coiled-coil prediction that expolits both single sequence and evolutionary information

Fariselli P.;
2009

Abstract

The coiled-coil is a widespread protein structural motif known to have a stabilization function and to be involved in key interactions in cells and organisms. Here we introduce a new program (PS-COILS) to address the problem of coiled-coil prediction. Furthermore, we select a new structurally-annotated and freely-available dataset of coiled-coil structures. We also show that PS-COILS performs better than the other available methods on the new dataset and we propose a new scoring schema that accounts for per-residue, per-segment and per-protein accuracy. The dataset and the PS-COILS code (under GPL-license) are available at www.biocomp.unibo.it/ lisa/CC. PS-COILS is also available at www.plone4bio.org through subversion interface.
SIXTH INTERNATIONAL MEETING ON COMPUTATIONAL INTELLIGENCE METHODS FOR BIOINFORMATICS AND BIOSTATISTICS
Genova
15-17 October 2009
Proceedings of CIBB 2009 (SIXTH INTERNATIONAL MEETING ON COMPUTATIONAL INTELLIGENCE METHODS FOR BIOINFORMATICS AND BIOSTATISTICS)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1687483
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