Patients with type 2 diabetes mellitus, carrying a single Sirtuin 1 (SIRT1) nucleotide polymorphism, the rs12778366, displayed lower SIRT1 expression after resveratrol supplementation but no differences on their metabolic or inflammatory variables. This suggests that this polymorphism does not impact on carriers’ clinical outcomes.
Rs12778366 single nucleotide polymorphism of Sirtuin 1 (SIRT1) and response to resveratrol supplementation in patients with type 2 diabetes mellitus.
Gambino R
First
;Fanni G;Togliatto G;Ponzo V;Goitre I;Cassader M;Brizzi MF
;Bo S.
Last
2019-01-01
Abstract
Patients with type 2 diabetes mellitus, carrying a single Sirtuin 1 (SIRT1) nucleotide polymorphism, the rs12778366, displayed lower SIRT1 expression after resveratrol supplementation but no differences on their metabolic or inflammatory variables. This suggests that this polymorphism does not impact on carriers’ clinical outcomes.
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Rs12778366 single nucleotide polymorphism of Sirtuin 1 (SIRT1) and response to resveratrol supplementation in patients with type 2 diabetes mellitus.pdf
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