Previous studies have demonstrated promising effects of a Chitosan-Membrane (CS-Me) for protection of neurovascular bundles on potency recovery in patients that undergo nerve sparing radical prostatectomy. The aim of this current study was many-fold: (1) to evaluate the neuro-regenerative potential of CS-Me on acutely axotomized autonomic neurons in vitro; (2) to rule out the possibility that a pro-regenerative biomaterial could interfere with the proliferation activity of prostate cancer cell lines; (3) to provide an in vivo proof of the biocompatibility and regeneration promoting effect of CS-Me in a standardized animal model of peripheral nerve injury and repair; (4) finally, to evaluate the tissue reaction induced by the degrading material.

New basic insights on the potential of chitosan-based medical device for improving functional recovery after radical prostatectomy

Muratori, L
Co-first
;
Fregnan, F
Co-first
;
Ronchi, G;Bertolo, R;Porpiglia, F
;
Geuna, S
Last
2019-01-01

Abstract

Previous studies have demonstrated promising effects of a Chitosan-Membrane (CS-Me) for protection of neurovascular bundles on potency recovery in patients that undergo nerve sparing radical prostatectomy. The aim of this current study was many-fold: (1) to evaluate the neuro-regenerative potential of CS-Me on acutely axotomized autonomic neurons in vitro; (2) to rule out the possibility that a pro-regenerative biomaterial could interfere with the proliferation activity of prostate cancer cell lines; (3) to provide an in vivo proof of the biocompatibility and regeneration promoting effect of CS-Me in a standardized animal model of peripheral nerve injury and repair; (4) finally, to evaluate the tissue reaction induced by the degrading material.
2019
124
6
1063
1076
autonomic ganglia; chitosan; nerve regeneration; prostate cancer
Muratori, L; Fregnan, F; Ronchi, G; Haastert-Talini, K; Metzen, J; Bertolo, R; Porpiglia, F; Geuna, S
File in questo prodotto:
File Dimensione Formato  
Muratori et al., BJUI.pdf

Accesso aperto

Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 1.39 MB
Formato Adobe PDF
1.39 MB Adobe PDF Visualizza/Apri
BJU International - 2019 - Muratori - New basic insights on the potential of a chitosan‐based medical device for improving.pdf

Accesso riservato

Tipo di file: PDF EDITORIALE
Dimensione 2.79 MB
Formato Adobe PDF
2.79 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1705072
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 3
social impact