Exaggerated Toll-like receptor (TLR)-mediated immune and inflammatory responses play a role in inflammatory bowel diseases. This report deals with the ability of a mixture of oxysterols widely present in cholesterol-rich foods to induce in vitro intestinal inflammation through TLR up-regulation. The anti-inflammatory action of four cocoa bean shell (CBS) extracts with different polyphenol content, was tested.

A Dietary Mixture of Oxysterols Induces In Vitro Intestinal Inflammation through TLR2/4 Activation: The Protective Effect of Cocoa Bean Shells

Rossin, Daniela;Barbosa-Pereira, Letricia;Iaia, Noemi;Testa, Gabriella;Sottero, Barbara;Poli, Giuseppe;Zeppa, Giuseppe;Biasi, Fiorella
Co-last
2019

Abstract

Exaggerated Toll-like receptor (TLR)-mediated immune and inflammatory responses play a role in inflammatory bowel diseases. This report deals with the ability of a mixture of oxysterols widely present in cholesterol-rich foods to induce in vitro intestinal inflammation through TLR up-regulation. The anti-inflammatory action of four cocoa bean shell (CBS) extracts with different polyphenol content, was tested.
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https://www.mdpi.com/journal/antioxidants
(−)-epicatechin; Honduras cocoa; IFNβ; IL-8; TNFα; Toll-like receptors; cocoa bean shell; dietary oxysterols; phenolic extract; tannins
Rossin, Daniela; Barbosa-Pereira, Letricia; Iaia, Noemi; Testa, Gabriella; Sottero, Barbara; Poli, Giuseppe; Zeppa, Giuseppe; Biasi, Fiorella
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1712105
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