Exaggerated Toll-like receptor (TLR)-mediated immune and inflammatory responses play a role in inflammatory bowel diseases. This report deals with the ability of a mixture of oxysterols widely present in cholesterol-rich foods to induce in vitro intestinal inflammation through TLR up-regulation. The anti-inflammatory action of four cocoa bean shell (CBS) extracts with different polyphenol content, was tested.

A Dietary Mixture of Oxysterols Induces In Vitro Intestinal Inflammation through TLR2/4 Activation: The Protective Effect of Cocoa Bean Shells

Rossin, Daniela;Barbosa-Pereira, Letricia;Iaia, Noemi;Testa, Gabriella;Sottero, Barbara;Poli, Giuseppe;Zeppa, Giuseppe;Biasi, Fiorella
Co-last
2019-01-01

Abstract

Exaggerated Toll-like receptor (TLR)-mediated immune and inflammatory responses play a role in inflammatory bowel diseases. This report deals with the ability of a mixture of oxysterols widely present in cholesterol-rich foods to induce in vitro intestinal inflammation through TLR up-regulation. The anti-inflammatory action of four cocoa bean shell (CBS) extracts with different polyphenol content, was tested.
2019
8
6
151
151
https://www.mdpi.com/journal/antioxidants
(−)-epicatechin; Honduras cocoa; IFNβ; IL-8; TNFα; Toll-like receptors; cocoa bean shell; dietary oxysterols; phenolic extract; tannins
Rossin, Daniela; Barbosa-Pereira, Letricia; Iaia, Noemi; Testa, Gabriella; Sottero, Barbara; Poli, Giuseppe; Zeppa, Giuseppe; Biasi, Fiorella
File in questo prodotto:
File Dimensione Formato  
antioxidants-08-00151.pdf

Accesso aperto

Descrizione: Articolo su rivista open access Antioxidants 2019
Tipo di file: PDF EDITORIALE
Dimensione 2.38 MB
Formato Adobe PDF
2.38 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1712105
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 30
  • ???jsp.display-item.citation.isi??? 29
social impact