The complexation of the bioactive compound oxyresveratrol (OXY) with a polymer called cyclodextrin-based nanosponge (CD-NS) and its application was studied.A new methodology is used to calculate, an apparent inclusion complex constant (KFapp) between a ligand and CD-NSs. Moreover, the KFapp of resveratrol was also evaluated and compared. The complex of OXY with the nanosponge β-CDI 1:4, was studied in vitro using DSC, TGA and FTIR techniques and its drug loading and release behavior were studied. An in vitro digestion showed higher protection of OXY complexed than free OXY. The bioactivity enhancing capacity of OXY was also studied against prostate (PC-3) and colon (HT-29 and HCT-116) cancer cell lines, where it showed stronger cell viability inhibition than the free drug. The findings as a whole represent a new opportunity for studying the complexation of drugs in CD-NSs and the use of oxyresveratrol as an ingredient in nutraceutical products.

Study of oxyresveratrol complexes with insoluble cyclodextrin based nanosponges: Developing a novel way to obtain their complexation constants and application in an anticancer study

Matencio A.;Dhakar N. K.;Bessone F.;Musso G.;Cavalli R.;Dianzani C.;Trotta F.
2020-01-01

Abstract

The complexation of the bioactive compound oxyresveratrol (OXY) with a polymer called cyclodextrin-based nanosponge (CD-NS) and its application was studied.A new methodology is used to calculate, an apparent inclusion complex constant (KFapp) between a ligand and CD-NSs. Moreover, the KFapp of resveratrol was also evaluated and compared. The complex of OXY with the nanosponge β-CDI 1:4, was studied in vitro using DSC, TGA and FTIR techniques and its drug loading and release behavior were studied. An in vitro digestion showed higher protection of OXY complexed than free OXY. The bioactivity enhancing capacity of OXY was also studied against prostate (PC-3) and colon (HT-29 and HCT-116) cancer cell lines, where it showed stronger cell viability inhibition than the free drug. The findings as a whole represent a new opportunity for studying the complexation of drugs in CD-NSs and the use of oxyresveratrol as an ingredient in nutraceutical products.
2020
231
115763
115769
http://www.elsevier.com/wps/find/journaldescription.cws_home/405871/description#description
Anticancer; Cyclodextrins; Methodology; Nanosponges; Oxyresveratrol; Stilbene
Matencio A.; Dhakar N.K.; Bessone F.; Musso G.; Cavalli R.; Dianzani C.; Garcia-Carmona F.; Lopez-Nicolas J.M.; Trotta F.
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0144861719314316-main.pdf

Accesso riservato

Tipo di file: PDF EDITORIALE
Dimensione 775.98 kB
Formato Adobe PDF
775.98 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
1-s2.0-S0144861719314316-mmc1.pdf

Accesso riservato

Tipo di file: PDF EDITORIALE
Dimensione 107.54 kB
Formato Adobe PDF
107.54 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Study of oxyresveratrol complexes with insoluble cyclodextrin based nanosponges.pdf

Accesso aperto

Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 561.96 kB
Formato Adobe PDF
561.96 kB Adobe PDF Visualizza/Apri
Supplementary Material_Study of oxyresveratrol complexes.pdf

Accesso aperto

Descrizione: Supplementary information
Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 111.37 kB
Formato Adobe PDF
111.37 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1729763
Citazioni
  • ???jsp.display-item.citation.pmc??? 25
  • Scopus 60
  • ???jsp.display-item.citation.isi??? 44
social impact