A new pullulan based doxorubicin macromolecular prodrug was synthesized and tested in vitro. Folic acid conjugation conferred to the supramolecular system active targeting properties. Doxorubicin was conjugated to pullulan via pH sensitive bonds yielding a derivative stable in plasma. At pH 5.5 the drug was completely released in 96 hours. The carrier was found to be selectively toxic to folate overexpressing cell lines.
Pullulan Bioconjugates For Tumor Targeting
SCOMPARIN A;SALMASO S.;CALICETI P
2009-01-01
Abstract
A new pullulan based doxorubicin macromolecular prodrug was synthesized and tested in vitro. Folic acid conjugation conferred to the supramolecular system active targeting properties. Doxorubicin was conjugated to pullulan via pH sensitive bonds yielding a derivative stable in plasma. At pH 5.5 the drug was completely released in 96 hours. The carrier was found to be selectively toxic to folate overexpressing cell lines.
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