No effective therapy is available for unresectable soft tissue sarcomas (STS). This unmet clinical need has prompted us to test whether chondroitin sulfate proteoglycan 4 (CSPG4)-specific CAR-redirected cytokine-induced killer lymphocytes (CAR.CIK) are effective in eliminating tumor cells derived from multiple STS histotypes in vitro and in immunodeficient mice.

CSPG4-specific CAR.CIK lymphocytes as a novel therapy for the treatment of multiple soft tissue sarcoma histotypes

Leuci, Valeria;Donini, Chiara;Mesiano, Giulia;Fiorino, Erika;Merlini, Alessandra;Medico, Enzo;Capellero, Sonia;Giraudo, Lidia;Cattaneo, Giulia;Iaia, Ilenia;Pignochino, Ymera;Vigna, Elisa;Fagioli, Franca;Aglietta, Massimo;Sangiolo, Dario
2020

Abstract

No effective therapy is available for unresectable soft tissue sarcomas (STS). This unmet clinical need has prompted us to test whether chondroitin sulfate proteoglycan 4 (CSPG4)-specific CAR-redirected cytokine-induced killer lymphocytes (CAR.CIK) are effective in eliminating tumor cells derived from multiple STS histotypes in vitro and in immunodeficient mice.
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https://clincancerres.aacrjournals.org/content/early/2020/09/05/1078-0432.CCR-20-0357.long
Leuci, Valeria; Donini, Chiara; Grignani, Giovanni; Rotolo, Ramona; Mesiano, Giulia; Fiorino, Erika; Gammaitoni, Loretta; D'Ambrosio, Lorenzo; Merlini, Alessandra; Landoni, Elisa; Medico, Enzo; Capellero, Sonia; Giraudo, Lidia; Cattaneo, Giulia; Iaia, Ilenia; Pignochino, Ymera; Basiricò, Marco; Vigna, Elisa; Pisacane, Alberto; Fagioli, Franca; Ferrone, Soldano; Aglietta, Massimo; Gianpietro, Dotti; Sangiolo, Dario
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1757318
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