Objectives: To validate and assess the reliability of the Italian version of self-administered ALSFRS-R, considering patients’ clinical and cognitive features and caregiver’s help. Methods: During the COVID-19 pandemic, by analyzing the results of 70 paired self-administered vs standard telephone-administered ALSFRS-R, we calculated overall score, single item scores, ALSFRS-R domain scores, King’s and MiToS stage inter-rater agreement and reliability using different validated methods. We created the Italian version of self-administered ALSFRS-R following ENCALS recommendation. Results: Correlation between the two scales was 0.94 and no systematic directional bias was found. The intraclass correlation coefficient (ICC) was very high (>0.90) for the vast majority of the considered classification criteria, especially King’s total score (0.96) and MiToS score (0.94). A higher ICC was found when the patients answered the questionnaire with the caregiver’s help (0.95). Conclusions: Online self-administered ALSFRS-R scale is a valid tool to stratify ALS patients into clinical stages and to implement telemedicine monitoring.

Validation of the Italian version of self-administered ALSFRS-R scale

Manera U.;Cabras S.;Daviddi M.;Vasta R.;Torrieri M. C.;Palumbo F.;Bombaci A.;Grassano M.;Solero L.;Peotta L.;Iazzolino B.;Canosa A.;Calvo A.;Chio A.;Moglia C.
2020

Abstract

Objectives: To validate and assess the reliability of the Italian version of self-administered ALSFRS-R, considering patients’ clinical and cognitive features and caregiver’s help. Methods: During the COVID-19 pandemic, by analyzing the results of 70 paired self-administered vs standard telephone-administered ALSFRS-R, we calculated overall score, single item scores, ALSFRS-R domain scores, King’s and MiToS stage inter-rater agreement and reliability using different validated methods. We created the Italian version of self-administered ALSFRS-R following ENCALS recommendation. Results: Correlation between the two scales was 0.94 and no systematic directional bias was found. The intraclass correlation coefficient (ICC) was very high (>0.90) for the vast majority of the considered classification criteria, especially King’s total score (0.96) and MiToS score (0.94). A higher ICC was found when the patients answered the questionnaire with the caregiver’s help (0.95). Conclusions: Online self-administered ALSFRS-R scale is a valid tool to stratify ALS patients into clinical stages and to implement telemedicine monitoring.
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ALSFRS-R; Amyotrophic lateral sclerosis; King’s staging system; MiToS staging system; telemedicine
Manera U.; Cabras S.; Daviddi M.; Vasta R.; Torrieri M.C.; Palumbo F.; Bombaci A.; Grassano M.; Solero L.; Peotta L.; Iazzolino B.; Canosa A.; Calvo A.; Chio A.; Moglia C.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1759757
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