A representative library of 3-(a-aryl)alkenylindoles has been prepared via a Brønsted-acid catalysed dehydrative coupling reaction between alkyl aryl ketones and some indoles. An interesting diastereoselectivity has been observed and has been explained from a mechanistic point of view.

Diastereoselective synthesis of 3-(a-aryl)alkenylindoles from the direct dehydrative coupling of indoles and ketones: A synthetic and theoretical study.

Margherita Barbero;Domenica Marabello;Stefano Dughera;Achille Antenucci;Giovanni Ghigo
2020-01-01

Abstract

A representative library of 3-(a-aryl)alkenylindoles has been prepared via a Brønsted-acid catalysed dehydrative coupling reaction between alkyl aryl ketones and some indoles. An interesting diastereoselectivity has been observed and has been explained from a mechanistic point of view.
2020
76
41
1
9
https://doi.org/10.1016/j.tet.2020.131498
3-(a-aryl)alkenylindoles Diastereoselective reaction Dehydrative coupling DFT calculations Indole functionalisation
Margherita Barbero, Domenica Marabello, Stefano Dughera, Tiziana Sicari, Achille Antenucci, Giovanni Ghigo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1762784
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