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EnglishThis prospective observational study aimed to evaluate whether women with SARS-CoV-2 infection during the first trimester of pregnancy are at higher risk of noninvasive prenatal screening test alterations and/or of congenital fetal anomalies at the second-trimester fetal anatomy scan. Maternal symptoms were secondly investigated. The study was carried out on 12-week pregnant women admitted for noninvasive prenatal testing (16 April and 22 June 2020). The cohort had seromolecular tests for SARS-CoV-2, after which they were divided into a positive case group and a negative control group. Both groups had 20-week ultrasound screening. Seventeen out of the 164 women tested positive for SARS-CoV-2 (10.3%). There were no significant differences in mean nuchal translucency thickness or biochemical markers (pregnancy-associated plasma protein A, alpha-fetoprotein, human chorionic gonadotropin, unconjugated estriol) between cases and controls (p = 0.77, 0.63, 0.30, 0.40, 0.28) or in the fetal incidence of structural anomalies at the second-trimester fetal anatomy scan (p = 0.21). No pneumonia or hospital admission due to COVID-19-related symptoms were observed. Asymptomatic or mildly symptomatic SARS-CoV-2 infection during the first trimester of pregnancy did not predispose affected women to more fetal anomalies than unaffected women. COVID-19 had a favorable maternal course at the beginning of pregnancy in our healthy cohort.
| Titolo: | Prenatal Biochemical and Ultrasound Markers in COVID-19 Pregnant Patients: A Prospective Case-Control Study | |
| Autori Riconosciuti: | ||
| Autori: | Cosma, Stefano; Carosso, Andrea Roberto; Borella, Fulvio; Cusato, Jessica; Bovetti, Marialuisa; Bevilacqua, Federica; Carosso, Marco; Gervasoni, Fiammetta; Sciarrone, Andrea; Marozio, Luca; Revelli, Alberto; Rolfo, Alessandro; Filippini, Claudia; Ghisetti, Valeria; Di Perri, Giovanni; Benedetto, Chiara | |
| Data di pubblicazione: | 2021 | |
| Abstract: | This prospective observational study aimed to evaluate whether women with SARS-CoV-2 infection during the first trimester of pregnancy are at higher risk of noninvasive prenatal screening test alterations and/or of congenital fetal anomalies at the second-trimester fetal anatomy scan. Maternal symptoms were secondly investigated. The study was carried out on 12-week pregnant women admitted for noninvasive prenatal testing (16 April and 22 June 2020). The cohort had seromolecular tests for SARS-CoV-2, after which they were divided into a positive case group and a negative control group. Both groups had 20-week ultrasound screening. Seventeen out of the 164 women tested positive for SARS-CoV-2 (10.3%). There were no significant differences in mean nuchal translucency thickness or biochemical markers (pregnancy-associated plasma protein A, alpha-fetoprotein, human chorionic gonadotropin, unconjugated estriol) between cases and controls (p = 0.77, 0.63, 0.30, 0.40, 0.28) or in the fetal incidence of structural anomalies at the second-trimester fetal anatomy scan (p = 0.21). No pneumonia or hospital admission due to COVID-19-related symptoms were observed. Asymptomatic or mildly symptomatic SARS-CoV-2 infection during the first trimester of pregnancy did not predispose affected women to more fetal anomalies than unaffected women. COVID-19 had a favorable maternal course at the beginning of pregnancy in our healthy cohort. | |
| Volume: | 11 (3) | |
| Fascicolo: | 398 | |
| Pagina iniziale: | 1 | |
| Pagina finale: | 11 | |
| Digital Object Identifier (DOI): | 10.3390/diagnostics11030398 | |
| Parole Chiave: | COVID-19; SARS-CoV-2; fetal congenital anomalies; fetus; first trimester; nuchal translucency; prenatal screening test; vertical transmission | |
| Rivista: | DIAGNOSTICS | |
| Appare nelle tipologie: | 03A-Articolo su Rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| diagnostics-11-00398-v2.pdf | PDF EDITORIALE | Open Access Visualizza/Apri |
http://hdl.handle.net/2318/1788004
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