Aim: To investigate near infrared-induced phototoxicity toward lung cancer cells, andthe biodegradability and effect on immune cells of glucose-derived carbon nanoparticles (CNPs). Methods: The human A549 lung adenocarcinoma cell line was used as a model to study the phototoxicity of CNPs. The biodegradability and the effect on immune cells was demonstrated in primary human neutrophils and macrophages. Results: Near infrared-activated CNPs elicited rapid cell death, characterized by the elevation of heat shock proteins and the induction of DNA damage. CNPs were found to be noncytotoxic toward primary human macrophages and were susceptible to biodegradation when cocultured with human neutrophils. Conclusions: Our results identify CNPs as promising platforms for photothermal therapy of lung cancer.

Efficacy, biocompatibility and degradability of carbon nanoparticles for photothermal therapy of lung cancer

Kokalari, Ida
First
;
Gazzano, Elena;Mandrile, Luisa;Giovannozzi, Andrea;Antonello, Giulia;Monopoli, Marco;Bergamaschi, Enrico;Riganti, Chiara;Fenoglio, Ivana
Last
2021-01-01

Abstract

Aim: To investigate near infrared-induced phototoxicity toward lung cancer cells, andthe biodegradability and effect on immune cells of glucose-derived carbon nanoparticles (CNPs). Methods: The human A549 lung adenocarcinoma cell line was used as a model to study the phototoxicity of CNPs. The biodegradability and the effect on immune cells was demonstrated in primary human neutrophils and macrophages. Results: Near infrared-activated CNPs elicited rapid cell death, characterized by the elevation of heat shock proteins and the induction of DNA damage. CNPs were found to be noncytotoxic toward primary human macrophages and were susceptible to biodegradation when cocultured with human neutrophils. Conclusions: Our results identify CNPs as promising platforms for photothermal therapy of lung cancer.
2021
16
9
689
707
biodegradation; carbon-based nanomaterials; immune cells; lung cancer; photothermal therapy
Kokalari, Ida; Keshavan, Sandeep; Rahman, Mizanur; Gazzano, Elena; Barzan, Giulia; Mandrile, Luisa; Giovannozzi, Andrea; Ponti, Jessica; Antonello, Giulia; Monopoli, Marco; Perrone, Guido; Bergamaschi, Enrico; Riganti, Chiara; Fadeel, Bengt; Fenoglio, Ivana
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1788063
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