Vasoplegia often complicates on-pump cardiac surgery. Systemic inflammatory response induced by extracorporeal circulation represents the major determinant, but adrenal insufficiency and postoperative vasopressin deficiency may have a role. Pathophysiological meaning of perioperative changes in endocrine markers of hydro-electrolyte balance has not still fully elucidated. Objectives of the present research study were to estimate the incidence of vasoplegia in a homogeneous cohort of not severe cardiopathic patients, to define the role of presurgical adrenal insufficiency, to evaluate copeptin and NT-proBNP trends in the perioperative.

Neuroendocrine predictors of vasoplegia after cardiopulmonary bypass

Berton, A M;Motta, G;Raffaldi, R;Fornaro, G;Costamagna, A;Filippini, C;Mengozzi, G;Prencipe, N;Zavattaro, M;Settanni, F;Ghigo, E;Brazzi, L;Benso, A S
2021

Abstract

Vasoplegia often complicates on-pump cardiac surgery. Systemic inflammatory response induced by extracorporeal circulation represents the major determinant, but adrenal insufficiency and postoperative vasopressin deficiency may have a role. Pathophysiological meaning of perioperative changes in endocrine markers of hydro-electrolyte balance has not still fully elucidated. Objectives of the present research study were to estimate the incidence of vasoplegia in a homogeneous cohort of not severe cardiopathic patients, to define the role of presurgical adrenal insufficiency, to evaluate copeptin and NT-proBNP trends in the perioperative.
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Adrenal insufficiency; Cardiac surgery; Copeptin; NT-proBNP; Shock; Vasopressin
Pasero, D; Berton, A M; Motta, G; Raffaldi, R; Fornaro, G; Costamagna, A; Toscano, A; Filippini, C; Mengozzi, G; Prencipe, N; Zavattaro, M; Settanni, F; Ghigo, E; Brazzi, L; Benso, A S
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1790902
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