Background: Healthcare-associated infections (HAIs) are an increasing public health threat. Measuring disease burden in disability-adjusted life-years (DALYs) allows the combination of morbidity and mortality into one figure, as it represents the summation of years lived with disability and years of life lost. Aim: To evaluate the incidence, attributable deaths and burden of the most significant HAIs in Italy. Methods: Prevalence data from the study sample of the 2016 national Point Prevalence Survey of HAIs in acute-care settings were used to estimate the incidence of five HAIs. The methodology from the Burden of Communicable Diseases in Europe (BCoDE)-project was employed for DALY calculations, adapting the disease models to the Italian population. Findings: We estimated a total of 641,065 (95% uncertainty interval, UI 585,543.00–699,207.90) new yearly cases of HAIs and 29,375 (95% UI 23,705.97–35,905.80) deaths in Italy in 2016. The total annual DALYs were estimated to be 424,657.45 (95% UI 346,240.35–513,357.28), corresponding to 702.53 DALYs (95% UI 575.22–844.66) per 100,000 general population. Bloodstream infections accounted for the majority of total DALYs (59%), healthcare-associated pneumonia for 29%, surgical site infections for 9%, CDI for 2% and urinary tract infections accounted for less than 1% of total DALYs. Conclusion: Results of this study suggest HAIs have a substantial burden in Italy. Reducing the burden of HAIs through infection prevention and control efforts is an achievable goal. This study provides data that could be used to guide policy-makers in the implementation of these measures.

Burden of healthcare-associated infections in Italy: incidence, attributable mortality and disability-adjusted life years (DALYs) from a nationwide study, 2016

Bordino V.;Vicentini C.;D'Ambrosio A.;Quattrocolo F.;Zotti C. M.
2021

Abstract

Background: Healthcare-associated infections (HAIs) are an increasing public health threat. Measuring disease burden in disability-adjusted life-years (DALYs) allows the combination of morbidity and mortality into one figure, as it represents the summation of years lived with disability and years of life lost. Aim: To evaluate the incidence, attributable deaths and burden of the most significant HAIs in Italy. Methods: Prevalence data from the study sample of the 2016 national Point Prevalence Survey of HAIs in acute-care settings were used to estimate the incidence of five HAIs. The methodology from the Burden of Communicable Diseases in Europe (BCoDE)-project was employed for DALY calculations, adapting the disease models to the Italian population. Findings: We estimated a total of 641,065 (95% uncertainty interval, UI 585,543.00–699,207.90) new yearly cases of HAIs and 29,375 (95% UI 23,705.97–35,905.80) deaths in Italy in 2016. The total annual DALYs were estimated to be 424,657.45 (95% UI 346,240.35–513,357.28), corresponding to 702.53 DALYs (95% UI 575.22–844.66) per 100,000 general population. Bloodstream infections accounted for the majority of total DALYs (59%), healthcare-associated pneumonia for 29%, surgical site infections for 9%, CDI for 2% and urinary tract infections accounted for less than 1% of total DALYs. Conclusion: Results of this study suggest HAIs have a substantial burden in Italy. Reducing the burden of HAIs through infection prevention and control efforts is an achievable goal. This study provides data that could be used to guide policy-makers in the implementation of these measures.
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Burden; DALY; Healthcare-associated infections; Italy
Bordino V.; Vicentini C.; D'Ambrosio A.; Quattrocolo F.; Novati R.; Sticchi C.; Bersani M.; Fedeli U.; Fabbri L.; Brusaferro S.; Moro M.L.; Ricchizzi E.; Poli A.; Giovannini G.; D'Errico M.; Puro V.; Parruti G.; Ripabelli G.; Sarnelli B.; Prato R.; Pavia M.; Agodi A.; Mura I.; Zotti C.M.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1795096
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