Hypoxia and HIFs (hypoxia inducible factors) are involved in chronic liver disease progression. We previously showed that hepatocyte HIF-2α activation significantly contributed to NAFLD progression in experimental animals and human patients. In this study we investigated mechanistically, using an appropriate genetic murine model, the involvement of hepatocyte HIF-2α in experimental NASH-related carcinogenesis.
Hepatocyte-specific deletion of HIF2α prevents NASH-related liver carcinogenesis by decreasing cancer cell proliferation
Foglia, BeatriceFirst
;Sutti, Salvatore;Cannito, Stefania;Rosso, Chiara;Maggiora, Marina;Autelli, Riccardo;Novo, Erica;Bocca, Claudia;Bugianesi, Elisabetta;Parola, MaurizioLast
2022-01-01
Abstract
Hypoxia and HIFs (hypoxia inducible factors) are involved in chronic liver disease progression. We previously showed that hepatocyte HIF-2α activation significantly contributed to NAFLD progression in experimental animals and human patients. In this study we investigated mechanistically, using an appropriate genetic murine model, the involvement of hepatocyte HIF-2α in experimental NASH-related carcinogenesis.
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