Hypogonadism in male and female: which is the best treatment?

intrOdUctiOn: subjects with hypo- or hypergonadotropic hypogonadism need hormone replacement therapy (Hrt) to initiate puberty and maintain it with a normal hormonal status. While general recommendations for the management of Hrt in adults have been published, no systematic suggestions focused on adolescents and young adults. the focus of this review is the Hrt in males and females with hypogonadism, from puberty to late reproductive age, covering the different management options, encompassing sex steroid or gonadotropin therapy, with discussion of benefits, limitations and specific considerations of the different treatments. EVIDENCE ACQUISITION: We conducted an extensive search in the 3 major scientific databases (PubMed, EMBASE and Google scholar) using the keywords “hormonal replacement therapy,” “hypogonadism,” “bone mineral density,” “estradiol/testosterone,” “puberty induction,” “delayed puberty.” case-control studies, case series, reviews and meta-analysis published in english ...