We designed a multicentre open prospective randomized trial to evaluate the risk-benefit profile of two different initial treatment schemes with levothyroxine (L-T4), 10-12.5 μg/kg/day vs 12.6-15 μg/kg/day, on growth and neurodevelopmental outcomes in children with congenital hypothyroidism (CH) detected by neonatal screening to identify the best range dose to achieve optimal neurocognitive development.

Effect of initial levothyroxine dose on neurodevelopmental and growth outcomes in children with congenital hypothyroidism

Mussa, Alessandro;
2022-01-01

Abstract

We designed a multicentre open prospective randomized trial to evaluate the risk-benefit profile of two different initial treatment schemes with levothyroxine (L-T4), 10-12.5 μg/kg/day vs 12.6-15 μg/kg/day, on growth and neurodevelopmental outcomes in children with congenital hypothyroidism (CH) detected by neonatal screening to identify the best range dose to achieve optimal neurocognitive development.
2022
13
923448
923448
congenital hypothyroidism; growth; levothyroxine treatment; neonatal screening; neurocognitive; Child, Preschool; Humans; Prospective Studies; Thyroid Hormones; Thyrotropin; Congenital Hypothyroidism; Thyroxine
Esposito, Andrea; Vigone, Maria Cristina; Polizzi, Miriam; Wasniewska, Malgorzata Gabriela; Cassio, Alessandra; Mussa, Alessandro; Gastaldi, Roberto; Di Mase, Raffaella; Vincenzi, Gaia; Pozzi, Clara; Peroni, Elena; Bravaccio, Carmela; Capalbo, Donatella; Bruzzese, Dario; Salerno, Mariacarolina
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1875479
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