Antibodies against the lymphocyte PD-1 (aPD-1) receptor are cornerstone agents for advanced non-small cell lung cancer (NSCLC), based on their ability to restore the exhausted antitumor immune response. Our study reports a novel, lymphocyte independent, therapeutic activity of aPD-1 against NSCLC, blocking the tumor-intrinsic PD-1 receptors on chemoresistant cells.

Novel lymphocyte-independent antitumor activity by PD-1 blocking antibody against PD-1+ chemoresistant lung cancer cells

Rotolo, Ramona;Leuci, Valeria;Donini, Chiara;Galvagno, Federica;Massa, Annamaria;De Santis, Maria Chiara;Peirone, Serena;Medico, Giovanni;Sanlorenzo, Martina;Righi, Luisella;Riganti, Chiara;Salaroglio, Iris Chiara;Napoli, Francesca;Tabbò, Fabrizio;Mariniello, Annapaola;Vigna, Elisa;Modica, Chiara;D'Ambrosio, Lorenzo;Taulli, Riccardo;Hirsch, Emilio;Cereda, Matteo;Aglietta, Massimo;Scagliotti, Giorgio Vittorio;Novello, Silvia;Bironzo, Paolo;Sangiolo, Dario
2022-01-01

Abstract

Antibodies against the lymphocyte PD-1 (aPD-1) receptor are cornerstone agents for advanced non-small cell lung cancer (NSCLC), based on their ability to restore the exhausted antitumor immune response. Our study reports a novel, lymphocyte independent, therapeutic activity of aPD-1 against NSCLC, blocking the tumor-intrinsic PD-1 receptors on chemoresistant cells.
Sep
27
1
14
https://doi.org/10.1158/1078-0432.CCR-22-0761
lymphocyte-independent, PD-1 blocking antibody against PD-1+, chemoresistant, lung cancer cells
Rotolo, Ramona; Leuci, Valeria; Donini, Chiara; Galvagno, Federica; Massa, Annamaria; De Santis, Maria Chiara; Peirone, Serena; Medico, Giovanni; Sanlorenzo, Martina; Vujic, Igor; Gammaitoni, Loretta; Basiricò, Marco; Righi, Luisella; Riganti, Chiara; Salaroglio, Iris Chiara; Napoli, Francesca; Tabbò, Fabrizio; Mariniello, Annapaola; Vigna, Elisa; Modica, Chiara; D'Ambrosio, Lorenzo; Grignani, Giovanni; Taulli, Riccardo; Hirsch, Emilio; Cereda, Matteo; Aglietta, Massimo; Scagliotti, Giorgio Vittorio; Novello, Silvia; Bironzo, Paolo; Sangiolo, Dario
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1878038
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