Achievements and Open Issues in the Determination of Polarized Parton Distribution Functions

I review the current status of the determination of helicity-dependent, or polarized, parton distribution functions from a comprehensive analysis of experimental data in perturbative quantum chromodynamics. I illustrate the latest achievements driven by new measurements in polarized proton-proton collisions at the Relativistic Heavy Ion Collider, namely the first evidence of a sizable polarized light sea quark asymmetry and of a positive polarized gluon distribution in the proton. I discuss which are the open issues in the determination of polarized distributions, and how these may be addressed in the future by ongoing, planned and proposed experimental programs.