Objective: To assess individual variation in anxiety, stress disorder, depression, insomnia, burnout and resilience in HCWs, 12 and 18 months after the beginning of Sars-Co-V2 pandemic. Methods: Prospective longitudinal study. Results: 207 HCWs (74% female, 46% physicians, 44% nurses) answered. 50% scored over the cut-off for anxiety (GAD-7), 66% for PCL-C, 41% for depression (PHQ-9), 25% for ISI and 15% started sleep inducers.52% showed emotional exhaustion (EE), 68% detachment (DE), 39% professional efficacy (EF) at MBI.27% completed the follow up questionnaire 6 months later, showing a significant reduction in nearly all scores (GAD7 median 11[5-15]vs7 [4-12](p<0,001); PCL-C 43[30-58]vs37[24-50] (p<0,05); PHQ-9 10[4-16]vs6 [3-12] (p<0,001); ISI 10[4-15]vs7[5-12](NS); MBI EE 25[16-35]vs23 [15-31] (NS), DE 13[8-17]vs12[8-17], EF 29[25-34]vs30[25-34].Living in a flat (OR 2.27(1.10-4.81), high-intensity-of-care working (2.83(1.15-7.16) increased risk of anxiety (GAD7); age between 31-40y(OR 2.8 (1.11-7.68), being a nurse(OR 3.56(1.59-8.36) and high-intensity-of-care working(OR 8.43(2.92-26.8) increased risk of pathological stress(PCL-C). Conclusions: Nearly half of HCWs showed psychological distress, especially nurses, women and the youngest. Mandatory job change, increasing intensity of care, working in COVID department and being infected were negative factors; having a partner and living in a detached house were protective. Six months later all the psychological domains showed individual improvement.
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