Background & aims: Non-alcoholic fatty liver disease (NAFLD) is a complex disease, resulting from the interplay between environmental determinants and genetic variations. Single nucleotide polymorphism (SNP) rs738409 C>G in the patatin-like phospholipase domain-containing 3 (PNPLA3) gene is associated with hepatic fibrosis and with higher risk of developing hepatocellular carcinoma. Here, we analysed a longitudinal cohort of biopsy-proven NAFLD subjects with the aim to identify individuals in whom genetics may have a stronger impact on disease progression. Methods: We retrospectively analyzed 756 consecutive, prospectively enrolled biopsy-proven NAFLD subjects from Italy, UK and Spain who were followed for a median of 84 months (interquartile range 65 - 109 months). We stratified the study cohort according to sex, body mass index (BMI)

Impact of PNPLA3 rs738409 polymorphism on the development of liver-related events in patients with non-alcoholic fatty liver disease

Rosso, Chiara
First
;
Caviglia, Gian Paolo;Birolo, Giovanni;Armandi, Angelo;Perez-Diaz-Del-Campo, Nuria;Castelnuovo, Gabriele;Olivero, Antonella;Abate, Maria Lorena;Ribaldone, Davide Giuseppe;Fariselli, Piero;Bugianesi, Elisabetta
Last
2023-01-01

Abstract

Background & aims: Non-alcoholic fatty liver disease (NAFLD) is a complex disease, resulting from the interplay between environmental determinants and genetic variations. Single nucleotide polymorphism (SNP) rs738409 C>G in the patatin-like phospholipase domain-containing 3 (PNPLA3) gene is associated with hepatic fibrosis and with higher risk of developing hepatocellular carcinoma. Here, we analysed a longitudinal cohort of biopsy-proven NAFLD subjects with the aim to identify individuals in whom genetics may have a stronger impact on disease progression. Methods: We retrospectively analyzed 756 consecutive, prospectively enrolled biopsy-proven NAFLD subjects from Italy, UK and Spain who were followed for a median of 84 months (interquartile range 65 - 109 months). We stratified the study cohort according to sex, body mass index (BMI)
2023
21
13
3314
3321
NAFLD; NASH; PNPLA3; liver-relate outcomes
Rosso, Chiara; Caviglia, Gian Paolo; Birolo, Giovanni; Armandi, Angelo; Pennisi, Grazia; Pelusi, Serena; Younes, Ramy; Liguori, Antonio; Perez-Diaz-De...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1903872
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