In BM samples from 91 AML WT1 expression levels were significantly higher (p=0.0004) than in 51 BM normal controls. No correlation was found with morfological, immunophenotypic, genetic and clinical features. A decrease of WT1 levels was detected in 20/23 AML patients following chemotherapy, and an increase in the WT1 expression level occurred before the hematologic relapse in 6 of them. Quantitative detection of WT1 may be integrated in the diagnosis of AML and used in MRD monitoring in cases lacking additional molecular markers.
Real time quantitative detection of WT1 gene transcript in acute myeloid leukemia
RIERA, Ludovica;PICH, Achille;
2006-01-01
Abstract
In BM samples from 91 AML WT1 expression levels were significantly higher (p=0.0004) than in 51 BM normal controls. No correlation was found with morfological, immunophenotypic, genetic and clinical features. A decrease of WT1 levels was detected in 20/23 AML patients following chemotherapy, and an increase in the WT1 expression level occurred before the hematologic relapse in 6 of them. Quantitative detection of WT1 may be integrated in the diagnosis of AML and used in MRD monitoring in cases lacking additional molecular markers.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
