The mechanical and biological behaviors of PMMA/Al2O3 composites incorporating 30 wt.%, 40 wt.%, and 50 wt.% of Al2O3 were thoroughly characterized as regards to their possible application in implant-supported prostheses. The Al2O3 particles accounted for an increase in the flexural modulus of PMMA. The highest value was recorded for the composite containing 40 wt.% Al2O3 (4.50 GPa), which was about 18% higher than that of its unfilled counterpart (3.86 GPa). The Al2O3 particles caused a decrease in the flexural strength of the composites, due to the presence of filler aggregates and voids, though it was still satisfactory for the intended application. The roughness (Ra) and water contact angle had the same trend, ranging from 1.94 & mu;m and 77.2 & DEG; for unfilled PMMA to 2.45 & mu;m and 105.8 & DEG; for the composite containing the highest alumina loading, respectively, hence influencing both the protein adsorption and cell adhesion. No cytotoxic effects were found, confirming that all the specimens are biocompatible and capable of sustaining cell growth and proliferation, without remarkable differences at 24 and 48 h. Finally, Al2O3 was able to cause strong cell responses (cell orientation), thus guiding the tissue formation in contact with the composite itself and not enhancing its osteoconductive properties, supporting the PMMA composite's usage in the envisaged application.

Mechanical and Biological Characterization of PMMA/Al2O3 Composites for Dental Implant Abutments

Roato, Ilaria;Genova, Tullio;Ruffinatti, Federico Alessandro;Zanin Venturini, Diletta;Di Maro, Mattia;Mosca Balma, Alessandro;Pedraza, Riccardo;Petrillo, Sara;Chinigò, Giorgia;Munaron, Luca;Faga, Maria Giulia;Mussano, Federico
2023-01-01

Abstract

The mechanical and biological behaviors of PMMA/Al2O3 composites incorporating 30 wt.%, 40 wt.%, and 50 wt.% of Al2O3 were thoroughly characterized as regards to their possible application in implant-supported prostheses. The Al2O3 particles accounted for an increase in the flexural modulus of PMMA. The highest value was recorded for the composite containing 40 wt.% Al2O3 (4.50 GPa), which was about 18% higher than that of its unfilled counterpart (3.86 GPa). The Al2O3 particles caused a decrease in the flexural strength of the composites, due to the presence of filler aggregates and voids, though it was still satisfactory for the intended application. The roughness (Ra) and water contact angle had the same trend, ranging from 1.94 & mu;m and 77.2 & DEG; for unfilled PMMA to 2.45 & mu;m and 105.8 & DEG; for the composite containing the highest alumina loading, respectively, hence influencing both the protein adsorption and cell adhesion. No cytotoxic effects were found, confirming that all the specimens are biocompatible and capable of sustaining cell growth and proliferation, without remarkable differences at 24 and 48 h. Finally, Al2O3 was able to cause strong cell responses (cell orientation), thus guiding the tissue formation in contact with the composite itself and not enhancing its osteoconductive properties, supporting the PMMA composite's usage in the envisaged application.
2023
15
15 art 3186
1
18
https://www.mdpi.com/2073-4360/15/15/3186
PMMA composites; alumina; cell adhesion; flexural modulus; osteoconductivity; viability
Roato, Ilaria; Genova, Tullio; Duraccio, Donatella; Ruffinatti, Federico Alessandro; Zanin Venturini, Diletta; Di Maro, Mattia; Mosca Balma, Alessandr...espandi
File in questo prodotto:
File Dimensione Formato  
polymers-15-03186 (1).pdf

Accesso aperto

Tipo di file: PDF EDITORIALE
Dimensione 4.66 MB
Formato Adobe PDF
4.66 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1931872
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 1
social impact