A targeted bibliographic search exposed the deficiencies within existing PROTAC preclinical pipelines, including missing, poor-quality data and technical limitations in the experimental assays. Several recommendations are proposed to improve the efficiency of preclinical platforms for PROTACs.
The Quest for Oral PROTAC drugs: Evaluating the Weaknesses of the Screening Pipeline
Apprato, GiuliaFirst
;Ermondi, Giuseppe;Caron, Giulia
Last
2023-01-01
Abstract
A targeted bibliographic search exposed the deficiencies within existing PROTAC preclinical pipelines, including missing, poor-quality data and technical limitations in the experimental assays. Several recommendations are proposed to improve the efficiency of preclinical platforms for PROTACs.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
Apprato2023QuestOralPROTACDrugs.pdf
Accesso aperto
Tipo di file:
PDF EDITORIALE
Dimensione
3.11 MB
Formato
Adobe PDF
|
3.11 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
