DNA Methyltransferase Gene Polymorphisms for Prediction of Radiation-induced Skin Fibrosis after Treatment of Breast Cancer: a Multifactorial Genetic Approach

This study was conducted to investigate the role of four polymorphic variants of DNA methyltransferase genes as risk factors for radiation-induced fibrosis in breast cancer patients. We also assessed their ability to improve prediction accuracy when combined with mitochondrial haplogroup H, which we previously found to be independently associated with a lower hazard of radiation-induced fibrosis.