Platelet rich plasma for primary macular hole: A case series

Objective: To evaluate the anatomical and functional macular results and rate of complications following surgical treatment of primary macular hole (MH) with autologous platelet rich plasma (a-PRP) use. Design: retrospective, interventional, non-randomized case series. Partecipants and methods: A cohort of 9 consecutive patients from January 1, 2019 to August 31, 2021 who underwent vitrectomy with a-PRP use for primary MH were included. Anatomical results based on spectral domain- optical coherence tomography (SD-OCT) and visual acuity were analyzed. Results: 10 pseudophakic eye of 9 patients were enrolled. Six patients were female and three patients were male. The mean age was 69.9 years +/- 1.48. The baseline MH minimum diameter was 486.1 mu m +/- 37.1, and mean pre operative best-corrected visual acuity (BCVA) was 0.91 +/- 0.03 logMAR (Snellen equivalent 20/160). Mean 1 month post operative BCVA was 0.81 +/- 0.57 logMAR (Snellen equivalent 20/130; p = 1.000); mean 3 month post operative BCVA was 0.66 +/- 0.04 logMAR (Snellen equivalent 20/90; p = 0.006); mean 6 month post operative BCVA was 0.6 +/- 0.04 logMAR (Snellen equivalent 20/80; p < 0.001). In all eyes, 10/10 (100%), there was a complete MH closure at 6 months follow up: 5 eyes (50%) with a U-type closure pattern, 4 eyes (40%) with a V-type pattern and 1 eye (10%) with an irregular foveal contour closure at 6 month follow-up. No ocular and systemic complications were reported. Conclusion: The a-PRP use is a successful and promising vitreoretinal surgical technique option for primary MH.