Irradiations at Ultra-High Dose Rate (UHDR) regimes, exceeding 40 Gy/s in single fractions lasting less than 200 ms, have shown an equivalent antitumor effect compared to conventional radiotherapy with reduced harm to normal tissues. This work details the hardware and software modifications implemented to deliver 10 MeV UHDR electron beams with a linear accelerator Elekta SL 18 MV and the beam characteristics obtained. GafChromic EBT XD films and an Advanced Markus chamber were used for dosimetry characterization, while a silicon sensor assessed the machine’s beam pulses stability and repeatability. The dose per pulse, average dose rate and instantaneous dose rate in the pulse were evaluated for four experimental settings, varying the source-to-surface distance and the beam collimation, i.e., with and without the use of a cylindrical applicator. The results showed a dose per pulse from 0.6 Gy to a few tens of Gy and an average dose rate up to 300 Gy/s. The obtained results demonstrate the possibility to perform in vitro radiobiology experiments and test new technologies for beam monitoring and dosimetry at the upgraded LINAC, thus contributing to the electron UHDR research field.

Characterization of a Modified Clinical Linear Accelerator for Ultra-High Dose Rate Beam Delivery

Deut, Umberto
First
;
Cirio, Roberto;Data, Emanuele Maria;Durisi, Elisabetta Alessandra;Ferrero, Veronica;Ferro, Arianna;Mas Milian, Felix;Medina, Elisabetta;Mostardi, Franco;Monti, Valeria;Sacchi, Roberto;Vignati, Anna
Last
2024-01-01

Abstract

Irradiations at Ultra-High Dose Rate (UHDR) regimes, exceeding 40 Gy/s in single fractions lasting less than 200 ms, have shown an equivalent antitumor effect compared to conventional radiotherapy with reduced harm to normal tissues. This work details the hardware and software modifications implemented to deliver 10 MeV UHDR electron beams with a linear accelerator Elekta SL 18 MV and the beam characteristics obtained. GafChromic EBT XD films and an Advanced Markus chamber were used for dosimetry characterization, while a silicon sensor assessed the machine’s beam pulses stability and repeatability. The dose per pulse, average dose rate and instantaneous dose rate in the pulse were evaluated for four experimental settings, varying the source-to-surface distance and the beam collimation, i.e., with and without the use of a cylindrical applicator. The results showed a dose per pulse from 0.6 Gy to a few tens of Gy and an average dose rate up to 300 Gy/s. The obtained results demonstrate the possibility to perform in vitro radiobiology experiments and test new technologies for beam monitoring and dosimetry at the upgraded LINAC, thus contributing to the electron UHDR research field.
2024
Inglese
Esperti anonimi
14
17
1
14
14
https://www.mdpi.com/2076-3417/14/17/7582
ultra-high dose rate, FLASH radiotherapy, LINAC; dosimetry, electron beam, silicon sensors, GafChromic films
BRASILE
   Compagnia di San Paolo - Bando ex-post - Anno 2020 - "Flash Monitoring Engine" - Cda 21/12/2021
   FLAME
   COMPAGNIA DI SAN PAOLO
   VIGNATI A.
1 – prodotto con file in versione Open Access (allegherò il file al passo 6 - Carica)
262
18
Deut, Umberto; Camperi, Aurora; Cavicchi, Cristiano; Cirio, Roberto; Data, Emanuele Maria; Durisi, Elisabetta Alessandra; Ferrero, Veronica; Ferro, Ar...espandi
info:eu-repo/semantics/article
open
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/2007810
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