Brain iron overload is a hallmark of many neurodegenerative diseases. Local chelating therapy poses many challenges due to the presence of very selective membranes and requires carriers of nanometric dimensions pushed by physical forces. Provided the carriers exhibit magnetic properties, magnetic fields already used in clinics, e.g. TMS, may drive them properly. The present study proposes the manufacturing of theranostic iron-chelating nanobubbles conjugated with SPIONs modulating their concentration to optimize initial driving and preserving the surface for effective chelation.
Magnetic Iron-Chelating Nanobubbles for Boosting Therapies Effectiveness in the CNS
Rizzo S. A.
;Stura I.;Scomparin A.;D'Agata F.;Cavalli R.;Guiot C.
2024-01-01
Abstract
Brain iron overload is a hallmark of many neurodegenerative diseases. Local chelating therapy poses many challenges due to the presence of very selective membranes and requires carriers of nanometric dimensions pushed by physical forces. Provided the carriers exhibit magnetic properties, magnetic fields already used in clinics, e.g. TMS, may drive them properly. The present study proposes the manufacturing of theranostic iron-chelating nanobubbles conjugated with SPIONs modulating their concentration to optimize initial driving and preserving the surface for effective chelation.
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