Liver metastases remain a major cause of death for colon cancer patients. We provide a novel approach for profiling protein signatures of liver metastasis microenvironments, with the aim of understanding the molecular mechanisms of metastatization, as well as of designing target diagnostic/therapeutic strategies. We report the identification of 203 human liver metastasis-binding peptides that mimic an extracellular signature of 177 networking proteins.
Peptidi metastasi-specifici e loro applicazioni diagnostiche e terapeutiche
BUSSOLINO, Federico;MARCHIO', Serena
2006-01-01
Abstract
Liver metastases remain a major cause of death for colon cancer patients. We provide a novel approach for profiling protein signatures of liver metastasis microenvironments, with the aim of understanding the molecular mechanisms of metastatization, as well as of designing target diagnostic/therapeutic strategies. We report the identification of 203 human liver metastasis-binding peptides that mimic an extracellular signature of 177 networking proteins.
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