The invention concerns a high yield assay for the identification of inhibitors of the expression of the oncoproteins E6 and E7 of the human papilloma virus (HPV), as well as a recombinant host cell suitable for use in the assay of the invention and a kit comprising such host cell. The assay and the kit of the invention enable the rapid screening of banks of molecules for the purpose of selecting compounds capable of inhibiting the expression of the oncoproteins E6 and E7 of HPV – in particular of high risk HPV – in tumour cells. Given their ability to inhibit the expression of the oncoproteins of HPV, the substances thus selected can be inserted in programmes for the development of drugs for the treatment of tumours induced by HPV.

Assay method for identifying inhibitors of the expression of the oncoproteins E6 and E7 of the human papilloma virus (Hpv), recombinant host cell and kit for use in the aforesaid method

LEMBO, David;LANDOLFO, Santo Giuseppe
2005-01-01

Abstract

The invention concerns a high yield assay for the identification of inhibitors of the expression of the oncoproteins E6 and E7 of the human papilloma virus (HPV), as well as a recombinant host cell suitable for use in the assay of the invention and a kit comprising such host cell. The assay and the kit of the invention enable the rapid screening of banks of molecules for the purpose of selecting compounds capable of inhibiting the expression of the oncoproteins E6 and E7 of HPV – in particular of high risk HPV – in tumour cells. Given their ability to inhibit the expression of the oncoproteins of HPV, the substances thus selected can be inserted in programmes for the development of drugs for the treatment of tumours induced by HPV.
PCT/EP2005/055598
Università degli studi di Torino
D. LEMBO; S. LANDOLFO
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/21268
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