Poor results with 131I-meta-iodobenzylguanidine (MIBG) therapy have been obtained in two children with stage IV neuroblastoma treated after partial surgery and unsatisfactory combination chemotherapy. Both patients' response to treatment (four and three 1-month-spaced courses, respectively; cumulative administration of 11.9 and 9.2 GBq) has been characterized by a low isotope concentration in the primary tumor and in the multiple bone metastases and by bone marrow uptake with final severe hematological toxicity. A slight decrease in the primary tumor's volume was observed in one patient at a cumulative dose of 85 Gy; there was no change in the other's at 42 Gy. At an initial, greater isotope concentration delivering 103 Gy, some bone metastases displayed a sharp decrease in uptake that persisted in the successive courses. For both patients a progressive spreading of new tumor localisation in the bones and finally in the soft tissues was observed.

131I-metaiodobenzylguanidine treatment in neuroblastoma: report of two cases. / COTTINO F; MUSSA GC; MADON E; FAVERO A; SILVESTRO L; GRAZIA G. - In: MEDICAL AND PEDIATRIC ONCOLOGY. - ISSN 0098-1532. - 15(4)(1987), pp. 216-219.

131I-metaiodobenzylguanidine treatment in neuroblastoma: report of two cases.

MADON, Enrico;SILVESTRO, Leandra;
1987

Abstract

Poor results with 131I-meta-iodobenzylguanidine (MIBG) therapy have been obtained in two children with stage IV neuroblastoma treated after partial surgery and unsatisfactory combination chemotherapy. Both patients' response to treatment (four and three 1-month-spaced courses, respectively; cumulative administration of 11.9 and 9.2 GBq) has been characterized by a low isotope concentration in the primary tumor and in the multiple bone metastases and by bone marrow uptake with final severe hematological toxicity. A slight decrease in the primary tumor's volume was observed in one patient at a cumulative dose of 85 Gy; there was no change in the other's at 42 Gy. At an initial, greater isotope concentration delivering 103 Gy, some bone metastases displayed a sharp decrease in uptake that persisted in the successive courses. For both patients a progressive spreading of new tumor localisation in the bones and finally in the soft tissues was observed.
15(4)
216
219
COTTINO F; MUSSA GC; MADON E; FAVERO A; SILVESTRO L; GRAZIA G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/35073
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