The aim of this study was to prepare solid lipid nanoparticles (SLNs) of octyl-p-methoxycinnamate (OMC) to improve the photostability of this UV adsorber. It was found that the rate of photodegradation is significantly dependent upon the initial concentration of the active substance and could be halved in SLN form. When different concentration of nonionic surfactant solutions were compared, it was found that OMC photodegraded more quickly from a medium containing fewer surfactant micelles. Photodegradation rate of OMC was investigated spectrophotometrically while nanoparticles were characterized by particle size examination, zeta potential determination, and thermal analysis.
Study on the photostability of Octyl-p-Methoxy Cinnamate in SLN
CARLOTTI, Maria Eugenia;SAPINO, Simona;VIONE, Davide Vittorio;PELIZZETTI, Ezio;UGAZIO, Elena;MOREL, Silvia
2005-01-01
Abstract
The aim of this study was to prepare solid lipid nanoparticles (SLNs) of octyl-p-methoxycinnamate (OMC) to improve the photostability of this UV adsorber. It was found that the rate of photodegradation is significantly dependent upon the initial concentration of the active substance and could be halved in SLN form. When different concentration of nonionic surfactant solutions were compared, it was found that OMC photodegraded more quickly from a medium containing fewer surfactant micelles. Photodegradation rate of OMC was investigated spectrophotometrically while nanoparticles were characterized by particle size examination, zeta potential determination, and thermal analysis.
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