A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.

Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants

CENA, Clara;BOSCHI, Donatella;CHEGAEV, Konstantin;LAZZARATO, Loretta;DI STILO, Antonella;ARAGNO, Manuela;FRUTTERO, Roberta;GASCO, Alberto
2004

Abstract

A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.
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C. CENA; D. BOSCHI; G.C. TRON; K. CHEGAEV; L. LAZZARATO; A. DI STILO; M. ARAGNO; R. FRUTTERO; A. GASCO
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/39274
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