A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.
Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants
CENA, Clara;BOSCHI, Donatella;CHEGAEV, Konstantin;LAZZARATO, Loretta;DI STILO, Antonella;ARAGNO, Manuela;FRUTTERO, Roberta;GASCO, Alberto
2004-01-01
Abstract
A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.
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