The relationship between nevirapine plasma concentrations and the durability of both viral suppression (VS) and selection of nevirapine primary resistance mutations (PRMs) was evaluated. A nevirapine trough concentration (Ctrough) of >4,300 ng/ml was found to predict longer VS. Patients with nevirapine Ctrough s ranging from 3,100 to 4,300 ng/ml had higher probabilities of developing PRMs than those with nevirapine Ctrough s below and above this concentration interval.

Nevirapine plasma exposure affects both durability of viral suppression and selection of nevirapine primary resistance mutations in a clinical setting

BONORA, Stefano;GARAZZINO, Silvia;D'AVOLIO, ANTONIO;DE ROSA, Francesco Giuseppe;SINICCO, Alessandro;DI PERRI, Giovanni
2005-01-01

Abstract

The relationship between nevirapine plasma concentrations and the durability of both viral suppression (VS) and selection of nevirapine primary resistance mutations (PRMs) was evaluated. A nevirapine trough concentration (Ctrough) of >4,300 ng/ml was found to predict longer VS. Patients with nevirapine Ctrough s ranging from 3,100 to 4,300 ng/ml had higher probabilities of developing PRMs than those with nevirapine Ctrough s below and above this concentration interval.
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GONZÁLEZ DE REQUENA D; BONORA S; GARAZZINO S; SCIANDRA M; D'AVOLIO A; RAITERI R; MARRONE R; BOFFITO M; DE ROSA FG; SINICCO A; DI PERRI G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/39294
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