Experiments of in vitro formation of blood vessels show that cells randomly spread on a gel matrix autonomously organize to form a connected vascular network. We propose a simple model which reproduces many features of the biological system. We show that both the model and the real system exhibit a fractal behavior at small scales, due to the process of migration and dynamical aggregation, followed at large scale by a random percolation behavior due to the coalescence of aggregates. The results are in good agreement with the analysis performed on the experimental data.

Percolation, morphogenesis, and burgers dynamics in blood vessels formation.

GIRAUDO, Enrico;SERINI, Guido;BUSSOLINO, Federico
2003-01-01

Abstract

Experiments of in vitro formation of blood vessels show that cells randomly spread on a gel matrix autonomously organize to form a connected vascular network. We propose a simple model which reproduces many features of the biological system. We show that both the model and the real system exhibit a fractal behavior at small scales, due to the process of migration and dynamical aggregation, followed at large scale by a random percolation behavior due to the coalescence of aggregates. The results are in good agreement with the analysis performed on the experimental data.
2003
90
118101
118101
Morphogenesis; Burgers dynamics; blood vessels; migration and dynamical aggregation
GAMBA A; AMBROSI D; CONIGLIO A; DE CANDIA A; DI TALIA S; E. GIRAUDO; SERINI G; PREZIOSI L; BUSSOLINO F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/40388
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