The stabilization of carbenium ions by an adjacent organotransition metal moiety has been evaluated using the classical Deno's method as well as a new procedure based on DCI-MS spectrometry. The ability of transition metal clusters to enhance the stability of a proximate carbocationic center in 17 alpha-alkynylestradiol-[OM] derivatives {[OM] = Co-2(CO)(6); Co-2(CO)(4)(dppm); Mo2Cp2(CO)(4); M-3(CO)(10), M = Ru, Os; HRu3(CO)(9)} has been related to their capacity to inactivate the estrogen receptor (affinity marker properties).

Stabilization of carbenium ions derived from ethynylestradiol by different adjacent organometallic moieties. Implication in the inactivation of the estrogen receptor

NERVI, Carlo;VINCENTI, Marco;
2000-01-01

Abstract

The stabilization of carbenium ions by an adjacent organotransition metal moiety has been evaluated using the classical Deno's method as well as a new procedure based on DCI-MS spectrometry. The ability of transition metal clusters to enhance the stability of a proximate carbocationic center in 17 alpha-alkynylestradiol-[OM] derivatives {[OM] = Co-2(CO)(6); Co-2(CO)(4)(dppm); Mo2Cp2(CO)(4); M-3(CO)(10), M = Ru, Os; HRu3(CO)(9)} has been related to their capacity to inactivate the estrogen receptor (affinity marker properties).
2000
-
491
497
METAL-CARBONYL CLUSTERS; X-RAY STRUCTURE; ESTRADIOL-RECEPTOR; COMPLEXES; DERIVATIVES; REACTIVITY; DINUCLEAR; CHEMISTRY; CO2(CO)6; CRYSTAL
D. Osella; M. Ravera; C. Nervi; G. Cavigiolio; M. Vincenti; A. Vessieres; G. Jaouen
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/44974
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