A motility disorder of the gastroesophageal tract may be involved in the pathogenesis of gastroesophageal reflux disease (GERD) in infants. The aim of this study was to evaluate the gastroesophageal tract activity in infants by a new method based on the simultaneous use of gastric scintigraphy, pH-monitoring and multiple intraluminal impedance (MII). Simultaneous gastric TC99 scintigraphy and Mll/pH monitoring were perfonned on 6 infants presenting apnoea crisis and clinica! suspicion of GERD. Data were collected for 180 min after the ingestion of a radiolabeled milk meal. The radionuclide counts series were fitted by a non linear least square software to obtain the gastric emptying curve. MII detected reflux events were mapped on the respective curve and were analyzed for composition, esophageal level, duration, pH, gastric emptying velocity and gastric filling state. Significance of data was established using proportional comparison test, t-test and Pearson correlation. Written consent was obtained from the parents. Conclusions: Combined MII/pHmonitoring/scintigraphy method resulted effective to provide new complementary information about gastric activity and reflux relationship in infants. Obtained data suggest gastric emptying patterns could have an influence on refluxes frequency and features.
Combined gastric emptying scintigraphy, ph-monitoring and intraesophageal multichannel impendance in infants
F. Cresi;SILVESTRO, Leandra
2005-01-01
Abstract
A motility disorder of the gastroesophageal tract may be involved in the pathogenesis of gastroesophageal reflux disease (GERD) in infants. The aim of this study was to evaluate the gastroesophageal tract activity in infants by a new method based on the simultaneous use of gastric scintigraphy, pH-monitoring and multiple intraluminal impedance (MII). Simultaneous gastric TC99 scintigraphy and Mll/pH monitoring were perfonned on 6 infants presenting apnoea crisis and clinica! suspicion of GERD. Data were collected for 180 min after the ingestion of a radiolabeled milk meal. The radionuclide counts series were fitted by a non linear least square software to obtain the gastric emptying curve. MII detected reflux events were mapped on the respective curve and were analyzed for composition, esophageal level, duration, pH, gastric emptying velocity and gastric filling state. Significance of data was established using proportional comparison test, t-test and Pearson correlation. Written consent was obtained from the parents. Conclusions: Combined MII/pHmonitoring/scintigraphy method resulted effective to provide new complementary information about gastric activity and reflux relationship in infants. Obtained data suggest gastric emptying patterns could have an influence on refluxes frequency and features.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.