2',2'-Difluoro-2'-deoxycytidine derivatives (I) are new. 2',2'-Difluoro-2'-deoxycytidine derivatives of formula (I) are new. R1-R3 each : hydrogen or hydrocarbyl acyl of at least 18C with a conformation that imparts the capacity for (I) to adapt a compacted form in polar solvent, provided at least one is other than hydrogen. Independent claims are also included for the following: (1) nanoparticles (NP) of (I); (2) method for preparing NP; and (3) use of squalenic acid (II), or its derivatives, for formulating at least one polar active agent of molecular weight over 100 as nanoparticles. [Image] - ACTIVITY : Cytostatic; Virucide. - MECHANISM OF ACTION : (I) is converted intracellularly into its triphosphate and when this is incorporated into replicating DNA, elongation is stopped, resulting in cell death.

Gemcitabine derivatives nanoparticles

ROCCO, Flavio;CATTEL, Luigi;STELLA, Barbara
2007

Abstract

2',2'-Difluoro-2'-deoxycytidine derivatives (I) are new. 2',2'-Difluoro-2'-deoxycytidine derivatives of formula (I) are new. R1-R3 each : hydrogen or hydrocarbyl acyl of at least 18C with a conformation that imparts the capacity for (I) to adapt a compacted form in polar solvent, provided at least one is other than hydrogen. Independent claims are also included for the following: (1) nanoparticles (NP) of (I); (2) method for preparing NP; and (3) use of squalenic acid (II), or its derivatives, for formulating at least one polar active agent of molecular weight over 100 as nanoparticles. [Image] - ACTIVITY : Cytostatic; Virucide. - MECHANISM OF ACTION : (I) is converted intracellularly into its triphosphate and when this is incorporated into replicating DNA, elongation is stopped, resulting in cell death.
EP1761551
CENTRE NAT RECH SCIENT (FR); UNIV PARIS SUD PARIS 11 (FR); ROCCO FLAVIO (IT)
Gemcitabine; nanoparticles
ROSILIO V; RENOIR JM; COUVREUR P; ROCCO F; CATTEL L; STELLA B
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/45372
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact