Abstract: The article addresses the design of multitarget drugs, namely compounds capable of interacting with more than one target simultaneously. These agents could be useful tools in the therapy of complex diseases such as cardiovascular and inflammatory diseases. An interesting case of multitarget compounds are nitric oxide (NO)-donor hybrids, structures which combine the physiological properties of NO with those of a lead drug. In particular the authors discuss the symbiotic approach used to design NO-donor non-steroidal anti-inflammatory drugs (NO-NSAIDs) and NO-donor antioxidants. The former could be useful agents in the treatment of anti-inflammatory diseases being devoid of gastro- and cardiotoxicity, the latter could be a valid approach to the treatment of many cardiovascular diseases.

Multitarget Drugs: Focus on the NO-donor hybrid drugs

GASCO, Alberto;BOSCHI, Donatella;CHEGAEV, Konstantin;CENA, Clara;DI STILO, Antonella;FRUTTERO, Roberta;LAZZARATO, Loretta;ROLANDO, Barbara;TOSCO, Paolo
2008

Abstract

Abstract: The article addresses the design of multitarget drugs, namely compounds capable of interacting with more than one target simultaneously. These agents could be useful tools in the therapy of complex diseases such as cardiovascular and inflammatory diseases. An interesting case of multitarget compounds are nitric oxide (NO)-donor hybrids, structures which combine the physiological properties of NO with those of a lead drug. In particular the authors discuss the symbiotic approach used to design NO-donor non-steroidal anti-inflammatory drugs (NO-NSAIDs) and NO-donor antioxidants. The former could be useful agents in the treatment of anti-inflammatory diseases being devoid of gastro- and cardiotoxicity, the latter could be a valid approach to the treatment of many cardiovascular diseases.
PURE AND APPLIED CHEMISTRY
80
1693
1701
Multitarget drugs; NO-donor hybrid drugs; NO-NSAIDs; NO-antioxidants; NO-donors; nitric oxide (NO)
Alberto Gasco; Donatella Boschi; Konstantin Chegaev; Clara Cena; Antonella Di Stilo; Roberta Fruttero; Loretta Lazzarato; Barbara Rolando; Paolo Tosco
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/46509
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