Testicular descent into the scrotal sacs is a complex multistep embryonic process influenced by anatomical and hormonal factors; the failure of this event results in a frequent congenital anomaly of the urogenital tract named cryptorchidism. The aetiology of this pathology is idiopathic, multifactorial and in part due to a disturbance in steroid hormone methabolism and of the enzymes involved in this pathway. In this work we considered the activity of an enzyme complex named 3 b-hydroxy- D5 – steroid dehydrogenase (3 b-HSD), which plays an important role in the conversion of - D5-3 b-hydroxysteroids to -D4-3 b-chetosteroids, and in particular in the testis it is involved in the synthesis of testosterone. We determined the activity of 3 b-HSD in two different step of the metabolism utilizing as substrates pregnenolone and dehydroepiandrosterone to establish a correlation between steroid synthesis and cryptorchidism in normal and abdominal pigs testis.

Attività della 3-beta-idrossisteroide deidrogenasi in testicoli criptorchidi di suino

MIOLETTI, Silvia;AMEDEO, Stefano;CAPUCCHIO, Maria Teresa;CURTO, Magda;GUARDA, Franco
2006

Abstract

Testicular descent into the scrotal sacs is a complex multistep embryonic process influenced by anatomical and hormonal factors; the failure of this event results in a frequent congenital anomaly of the urogenital tract named cryptorchidism. The aetiology of this pathology is idiopathic, multifactorial and in part due to a disturbance in steroid hormone methabolism and of the enzymes involved in this pathway. In this work we considered the activity of an enzyme complex named 3 b-hydroxy- D5 – steroid dehydrogenase (3 b-HSD), which plays an important role in the conversion of - D5-3 b-hydroxysteroids to -D4-3 b-chetosteroids, and in particular in the testis it is involved in the synthesis of testosterone. We determined the activity of 3 b-HSD in two different step of the metabolism utilizing as substrates pregnenolone and dehydroepiandrosterone to establish a correlation between steroid synthesis and cryptorchidism in normal and abdominal pigs testis.
Congresso Nazionale S.I.P.A.S.
Modena
23-24 marzo 2006
Atti S.I.P.A.S. 2006
S.I.P.A.S.
349
352
pigs; testis; cryptorchidism; 3 b-hydroxy- D5 – steroid dehydrogenase
Mioletti S.; Amedeo S.; Apicella M.;Giberti M.; Cerutti F.;Capucchio M.T.; Curto M. ; Bruno R.; Guarda F.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/51193
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