2',2'-Difluoro-2'-deoxycytidine derivatives (I) are new. 2',2'-Difluoro-2'-deoxycytidine derivatives of formula (I) are new. R1-R3 each : hydrogen or hydrocarbyl acyl of at least 18C with a conformation that imparts the capacity for (I) to adapt a compacted form in polar solvent, provided at least one is other than hydrogen. Independent claims are also included for the following: (1) nanoparticles (NP) of (I); (2) method for preparing NP; and (3) use of squalenic acid (II), or its derivatives, for formulating at least one polar active agent of molecular weight over 100 as nanoparticles. [Image] - ACTIVITY : Cytostatic; Virucide. - MECHANISM OF ACTION : (I) is converted intracellularly into its triphosphate and when this is incorporated into replicating DNA, elongation is stopped, resulting in cell death.

New difluoro-2'-deoxycytidine derivatives, useful as anticancer and antiviral agents, contain residue that promotes formation of nanoparticles and increases stability in serum

STELLA, Barbara;CATTEL, Luigi;ROCCO, Flavio;
2006

Abstract

2',2'-Difluoro-2'-deoxycytidine derivatives (I) are new. 2',2'-Difluoro-2'-deoxycytidine derivatives of formula (I) are new. R1-R3 each : hydrogen or hydrocarbyl acyl of at least 18C with a conformation that imparts the capacity for (I) to adapt a compacted form in polar solvent, provided at least one is other than hydrogen. Independent claims are also included for the following: (1) nanoparticles (NP) of (I); (2) method for preparing NP; and (3) use of squalenic acid (II), or its derivatives, for formulating at least one polar active agent of molecular weight over 100 as nanoparticles. [Image] - ACTIVITY : Cytostatic; Virucide. - MECHANISM OF ACTION : (I) is converted intracellularly into its triphosphate and when this is incorporated into replicating DNA, elongation is stopped, resulting in cell death.
FR2874016 (A1)
CENTRE NAT RECH SCIENT; UNIV PARIS SUD; ROCCO FLAVIO
Gemcitabine; nanoparticles; anticancer agents; antiviral agents
STELLA B; CATTEL L; ROCCO F; COUVREUR P; RENOIR JM; ROSILIO V
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/51578
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